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N-Acetyl cysteine ameliorates hyperglycemia-induced cardiomyocyte toxicity by improving mitochondrial energetics and enhancing endogenous Coenzyme Q9/10 levels.
Dludla PV, Orlando P, Silvestri S, Mazibuko-Mbeje SE, Johnson R, Marcheggiani F, Cirilli I, Muller CJF, Louw J, Obonye N, Nyawo T, Nkambule BB, Tiano L. Dludla PV, et al. Among authors: orlando p. Toxicol Rep. 2019 Nov 5;6:1240-1245. doi: 10.1016/j.toxrep.2019.11.004. eCollection 2019. Toxicol Rep. 2019. PMID: 31799124 Free PMC article.
Palmitate-induced toxicity is associated with impaired mitochondrial respiration and accelerated oxidative stress in cultured cardiomyocytes: The critical role of coenzyme Q9/10.
Dludla PV, Silvestri S, Orlando P, Mazibuko-Mbeje SE, Johnson R, Marcheggiani F, Cirilli I, Muller CJF, Louw J, Chellan N, Obonye N, Nkambule BB, Tiano L. Dludla PV, et al. Among authors: orlando p. Toxicol In Vitro. 2020 Oct;68:104948. doi: 10.1016/j.tiv.2020.104948. Epub 2020 Jul 16. Toxicol In Vitro. 2020. PMID: 32683093
Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration.
Mazibuko-Mbeje SE, Dludla PV, Johnson R, Joubert E, Louw J, Ziqubu K, Tiano L, Silvestri S, Orlando P, Opoku AR, Muller CJF. Mazibuko-Mbeje SE, et al. Among authors: orlando p. PLoS One. 2019 May 2;14(5):e0216172. doi: 10.1371/journal.pone.0216172. eCollection 2019. PLoS One. 2019. PMID: 31048842 Free PMC article.
Modulation of Coenzyme Q10 content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging.
Marcheggiani F, Cirilli I, Orlando P, Silvestri S, Vogelsang A, Knott A, Blatt T, Weise JM, Tiano L. Marcheggiani F, et al. Among authors: orlando p. Aging (Albany NY). 2019 May 10;11(9):2565-2582. doi: 10.18632/aging.101926. Aging (Albany NY). 2019. PMID: 31076563 Free PMC article.
Exploring the Comparative Efficacy of Metformin and Resveratrol in the Management of Diabetes-associated Complications: A Systematic Review of Preclinical Studies.
Dludla PV, Silvestri S, Orlando P, Gabuza KB, Mazibuko-Mbeje SE, Nyambuya TM, Mxinwa V, Mokgalaboni K, Johnson R, Muller CJF, Tiano L, Louw J, Nkambule BB. Dludla PV, et al. Among authors: orlando p. Nutrients. 2020 Mar 11;12(3):739. doi: 10.3390/nu12030739. Nutrients. 2020. PMID: 32168855 Free PMC article.
293 results