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Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm.
Wu Z, Shen S, Mizikovsky D, Cao Y, Naval-Sanchez M, Tan SZ, Alvarez YD, Sun Y, Chen X, Zhao Q, Kim D, Yang P, Hill TA, Jones A, Fairlie DP, Pébay A, Hewitt AW, Tam PPL, White MD, Nefzger CM, Palpant NJ. Wu Z, et al. Among authors: nefzger cm. Dev Cell. 2024 Mar 25;59(6):705-722.e8. doi: 10.1016/j.devcel.2024.01.019. Epub 2024 Feb 13. Dev Cell. 2024. PMID: 38354738
Transient naive reprogramming corrects hiPS cells functionally and epigenetically.
Buckberry S, Liu X, Poppe D, Tan JP, Sun G, Chen J, Nguyen TV, de Mendoza A, Pflueger J, Frazer T, Vargas-Landín DB, Paynter JM, Smits N, Liu N, Ouyang JF, Rossello FJ, Chy HS, Rackham OJL, Laslett AL, Breen J, Faulkner GJ, Nefzger CM, Polo JM, Lister R. Buckberry S, et al. Among authors: nefzger cm. Nature. 2023 Aug;620(7975):863-872. doi: 10.1038/s41586-023-06424-7. Epub 2023 Aug 16. Nature. 2023. PMID: 37587336 Free PMC article.
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release.
Labzin LI, Chew KY, Eschke K, Wang X, Esposito T, Stocks CJ, Rae J, Patrick R, Mostafavi H, Hill B, Yordanov TE, Holley CL, Emming S, Fritzlar S, Mordant FL, Steinfort DP, Subbarao K, Nefzger CM, Lagendijk AK, Gordon EJ, Parton RG, Short KR, Londrigan SL, Schroder K. Labzin LI, et al. Among authors: nefzger cm. Sci Signal. 2023 Apr 25;16(782):eabq1366. doi: 10.1126/scisignal.abq1366. Epub 2023 Apr 25. Sci Signal. 2023. PMID: 37098119
High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production.
Heazlewood SY, Ahmad T, Cao B, Cao H, Domingues M, Sun X, Heazlewood CK, Li S, Williams B, Fulton M, White JF, Nebl T, Nefzger CM, Polo JM, Kile BT, Kraus F, Ryan MT, Sun YB, Choong PFM, Ellis SL, Anko ML, Nilsson SK. Heazlewood SY, et al. Among authors: nefzger cm. Nat Commun. 2023 Apr 13;14(1):2099. doi: 10.1038/s41467-023-37780-7. Nat Commun. 2023. PMID: 37055407 Free PMC article.
Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential.
Nefzger CM, Jardé T, Srivastava A, Schroeder J, Rossello FJ, Horvay K, Prasko M, Paynter JM, Chen J, Weng CF, Sun YBY, Liu X, Chan E, Deshpande N, Chen X, Li YJ, Pflueger J, Engel RM, Knaupp AS, Tsyganov K, Nilsson SK, Lister R, Rackham OJL, Abud HE, Polo JM. Nefzger CM, et al. NPJ Regen Med. 2022 Jun 16;7(1):31. doi: 10.1038/s41536-022-00226-7. NPJ Regen Med. 2022. PMID: 35710627 Free PMC article.
48 results