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Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death.
J Med Chem. 2024 Apr 25;67(8):5999-6026. doi: 10.1021/acs.jmedchem.3c02112. Epub 2024 Apr 5.
J Med Chem. 2024.
PMID: 38580317
Free PMC article.
Review.
Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress.
Gordon-Blake J, Ratia K, Weidig V, Velma GR, Ackerman-Berrier M, Penton C, Musku SR, Alves ETM, Driver T, Tai L, Thatcher GRJ.
Gordon-Blake J, et al. Among authors: velma gr.
ACS Med Chem Lett. 2024 Jan 24;15(2):205-214. doi: 10.1021/acsmedchemlett.3c00391. eCollection 2024 Feb 8.
ACS Med Chem Lett. 2024.
PMID: 38352833
Free PMC article.
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Synthesis, Optimization, and Structure-Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs).
Shen Z, Ratia K, Krider I, Ackerman-Berrier M, Penton C, Musku SR, Gordon-Blake JM, Laham MS, Christie N, Ma N, Fu J, Xiong R, Courey JM, Velma GR, Thatcher GRJ.
Shen Z, et al. Among authors: velma gr.
J Med Chem. 2023 Dec 28;66(24):16704-16727. doi: 10.1021/acs.jmedchem.3c01406. Epub 2023 Dec 14.
J Med Chem. 2023.
PMID: 38096366
Free article.
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Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD.
Ratia KM, Shen Z, Gordon-Blake J, Lee H, Laham MS, Krider IS, Christie N, Ackerman-Berrier M, Penton C, Knowles NG, Musku SR, Fu J, Velma GR, Xiong R, Thatcher GRJ.
Ratia KM, et al. Among authors: velma gr.
Biochemistry. 2023 Feb 21;62(4):923-933. doi: 10.1021/acs.biochem.2c00655. Epub 2023 Feb 6.
Biochemistry. 2023.
PMID: 36746631
Free PMC article.
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Dinuclear orthometallated gold(I)-gold(III) anticancer complexes with potent in vivo activity through an ROS-dependent mechanism.
Mirzadeh N, Telukutla SR, Luwor R, Privér S, Velma GR, Jakku RK, Andrew N S, Plebanski M, Christian H, Bhargava S.
Mirzadeh N, et al. Among authors: velma gr.
Metallomics. 2021 Jul 15;13(7):mfab039. doi: 10.1093/mtomcs/mfab039.
Metallomics. 2021.
PMID: 34165566
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Identification and characterization of forced degradation products of vortioxetine by LC/MS/MS and NMR.
Ragi NC, Velma GR, Pallerla PK, Siddiqua S, Alugonda V, Rachamalla HKR, Pabbaraja S, Sripadi P.
Ragi NC, et al. Among authors: velma gr.
J Pharm Biomed Anal. 2020 Sep 5;188:113442. doi: 10.1016/j.jpba.2020.113442. Epub 2020 Jun 27.
J Pharm Biomed Anal. 2020.
PMID: 32622114
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