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GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment.
Worley BL, Kim YS, Mardini J, Zaman R, Leon KE, Vallur PG, Nduwumwami A, Warrick JI, Timmins PF, Kesterson JP, Phaëton R, Lee NY, Walter V, Endres L, Mythreye K, Aird KM, Hempel N. Worley BL, et al. Among authors: aird km. Redox Biol. 2019 Jul;25:101051. doi: 10.1016/j.redox.2018.11.009. Epub 2018 Nov 17. Redox Biol. 2019. PMID: 30509602 Free PMC article.
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.
Kim YS, Gupta Vallur P, Jones VM, Worley BL, Shimko S, Shin DH, Crawford LC, Chen CW, Aird KM, Abraham T, Shepherd TG, Warrick JI, Lee NY, Phaeton R, Mythreye K, Hempel N. Kim YS, et al. Among authors: aird km. Oncogene. 2020 Feb;39(8):1619-1633. doi: 10.1038/s41388-019-1097-7. Epub 2019 Nov 13. Oncogene. 2020. PMID: 31723239 Free PMC article.
αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation.
Uboveja A, Huang Z, Buj R, Amalric A, Wang H, Tangudu NK, Cole AR, Megill E, Kantner D, Chatoff A, Ahmad H, Marcinkiewicz MM, Disharoon JA, Graff S, Dahl ES, Hempel N, Stallaert W, Sidoli S, Bitler BG, Long DT, Snyder NW, Aird KM. Uboveja A, et al. Among authors: aird km. bioRxiv [Preprint]. 2024 Feb 11:2024.02.06.578742. doi: 10.1101/2024.02.06.578742. bioRxiv. 2024. PMID: 38370789 Free PMC article. Preprint.
De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression.
Tangudu NK, Buj R, Wang H, Wang J, Cole AR, Uboveja A, Fang R, Amalric A, Yang B, Chatoff A, Crispim CV, Sajjakulnukit P, Lyons MA, Cooper K, Hempel N, Lyssiotis CA, Chandran UR, Snyder NW, Aird KM. Tangudu NK, et al. Among authors: aird km. Cancer Res Commun. 2024 May 2;4(5):1174-1188. doi: 10.1158/2767-9764.CRC-23-0450. Cancer Res Commun. 2024. PMID: 38626341 Free PMC article.
NFATC4 promotes quiescence and chemotherapy resistance in ovarian cancer.
Cole AJ, Iyengar M, Panesso-Gómez S, O'Hayer P, Chan D, Delgoffe GM, Aird KM, Yoon E, Bai S, Buckanovich RJ. Cole AJ, et al. Among authors: aird km. JCI Insight. 2020 Apr 9;5(7):e131486. doi: 10.1172/jci.insight.131486. JCI Insight. 2020. PMID: 32182216 Free PMC article.
Alternative splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and tumor progression in ovarian cancer.
Javed Z, Shin DH, Pan W, White SR, Kim YS, Elhaw AT, Kamlapurkar S, Cheng YY, Benson JC, Abdelnaby AE, Phaëton R, Wang HG, Yang S, Sullivan MLG, St Croix CM, Watkins SC, Mullett SJ, Gelhaus SL, Lee N, Coffman LG, Aird KM, Trebak M, Mythreye K, Walter V, Hempel N. Javed Z, et al. Among authors: aird km. bioRxiv [Preprint]. 2024 Jan 24:2023.09.20.558501. doi: 10.1101/2023.09.20.558501. bioRxiv. 2024. PMID: 37790404 Free PMC article. Preprint.
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