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Activity and safety of enobosarm, a novel, oral, selective androgen receptor modulator, in androgen receptor-positive, oestrogen receptor-positive, and HER2-negative advanced breast cancer (Study G200802): a randomised, open-label, multicentre, multinational, parallel design, phase 2 trial.
Palmieri C, Linden H, Birrell SN, Wheelwright S, Lim E, Schwartzberg LS, Dwyer AR, Hickey TE, Rugo HS, Cobb P, O'Shaughnessy JA, Johnston S, Brufsky A, Tilley WD, Overmoyer B. Palmieri C, et al. Among authors: tilley wd. Lancet Oncol. 2024 Mar;25(3):317-325. doi: 10.1016/S1470-2045(24)00004-4. Epub 2024 Feb 8. Lancet Oncol. 2024. PMID: 38342115 Free article. Clinical Trial.
Library size confounds biology in spatial transcriptomics data.
Bhuva DD, Tan CW, Salim A, Marceaux C, Pickering MA, Chen J, Kharbanda M, Jin X, Liu N, Feher K, Putri G, Tilley WD, Hickey TE, Asselin-Labat ML, Phipson B, Davis MJ. Bhuva DD, et al. Among authors: tilley wd. Genome Biol. 2024 Apr 18;25(1):99. doi: 10.1186/s13059-024-03241-7. Genome Biol. 2024. PMID: 38637899 Free PMC article.
ACSM1 and ACSM3 regulate fatty acid metabolism to support prostate cancer growth and constrain ferroptosis.
Shrestha RK, Nassar ZD, Hanson AR, Iggo R, Townley SL, Dehairs J, Mah CY, Helm M, Alizadeh-Ghodsi M, Pickering M, Ghesquiere B, Watt MJ, Quek LE, Hoy AJ, Tilley WD, Swinnen JV, Butler LM, Selth LA. Shrestha RK, et al. Among authors: tilley wd. Cancer Res. 2024 Apr 24. doi: 10.1158/0008-5472.CAN-23-1489. Online ahead of print. Cancer Res. 2024. PMID: 38657108
Selective inhibition of CDK9 in triple negative breast cancer.
Mustafa EH, Laven-Law G, Kikhtyak Z, Nguyen V, Ali S, Pace AA, Iggo R, Kebede A, Noll B, Wang S, Winter JM, Dwyer AR, Tilley WD, Hickey TE. Mustafa EH, et al. Among authors: tilley wd. Oncogene. 2024 Jan;43(3):202-215. doi: 10.1038/s41388-023-02892-3. Epub 2023 Nov 24. Oncogene. 2024. PMID: 38001268 Free PMC article.
Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer.
Alizadeh-Ghodsi M, Owen KL, Townley SL, Zanker D, Rollin SPG, Hanson AR, Shrestha R, Toubia J, Gargett T, Chernukhin I, Luu J, Cowley KJ, Clark A, Carroll JS, Simpson KJ, Winter JM, Lawrence MG, Butler LM, Risbridger GP, Thierry B, Taylor RA, Hickey TE, Parker BS, Tilley WD, Selth LA. Alizadeh-Ghodsi M, et al. Among authors: tilley wd. Cancer Res Commun. 2022 Jul 25;2(7):706-724. doi: 10.1158/2767-9764.CRC-21-0139. eCollection 2022 Jul. Cancer Res Commun. 2022. PMID: 36923279 Free PMC article.
A cell permeable bimane-constrained PCNA-interacting peptide.
Horsfall AJ, Vandborg BA, Kikhtyak Z, Scanlon DB, Tilley WD, Hickey TE, Bruning JB, Abell AD. Horsfall AJ, et al. Among authors: tilley wd. RSC Chem Biol. 2021 Jul 21;2(5):1499-1508. doi: 10.1039/d1cb00113b. eCollection 2021 Oct 7. RSC Chem Biol. 2021. PMID: 34704055 Free PMC article.
Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition.
Butler LM, Mah CY, Machiels J, Vincent AD, Irani S, Mutuku SM, Spotbeen X, Bagadi M, Waltregny D, Moldovan M, Dehairs J, Vanderhoydonc F, Bloch K, Das R, Stahl J, Kench JG, Gevaert T, Derua R, Waelkens E, Nassar ZD, Selth LA, Trim PJ, Snel MF, Lynn DJ, Tilley WD, Horvath LG, Centenera MM, Swinnen JV. Butler LM, et al. Among authors: tilley wd. Cancer Res. 2021 Oct 1;81(19):4981-4993. doi: 10.1158/0008-5472.CAN-20-3863. Epub 2021 Aug 6. Cancer Res. 2021. PMID: 34362796
213 results