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The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity.
Espinoza JA, Zisi A, Kanellis DC, Carreras-Puigvert J, Henriksson M, Hühn D, Watanabe K, Helleday T, Lindström MS, Bartek J. Espinoza JA, et al. Among authors: lindstrom ms. Cell Death Differ. 2020 Feb;27(2):773-789. doi: 10.1038/s41418-019-0387-5. Epub 2019 Jul 8. Cell Death Differ. 2020. PMID: 31285544 Free PMC article.
The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output.
Kanellis DC, Espinoza JA, Zisi A, Sakkas E, Bartkova J, Katsori AM, Boström J, Dyrskjøt L, Broholm H, Altun M, Elsässer SJ, Lindström MS, Bartek J. Kanellis DC, et al. Among authors: lindstrom ms. Sci Adv. 2021 Aug 4;7(32):eabf7561. doi: 10.1126/sciadv.abf7561. Print 2021 Aug. Sci Adv. 2021. PMID: 34348895 Free PMC article.
Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET.
Kanellis DC, Zisi A, Skrott Z, Lemmens B, Espinoza JA, Kosar M, Björkman A, Li X, Arampatzis S, Bartkova J, Andújar-Sánchez M, Fernandez-Capetillo O, Mistrik M, Lindström MS, Bartek J. Kanellis DC, et al. Among authors: lindstrom ms. Cell Death Differ. 2023 Jul;30(7):1666-1678. doi: 10.1038/s41418-023-01167-4. Epub 2023 May 4. Cell Death Differ. 2023. PMID: 37142656 Free PMC article.
DNA damage-induced dynamic changes in abundance and cytosol-nuclear translocation of proteins involved in translational processes, metabolism, and autophagy.
Bennetzen MV, Kosar M, Bunkenborg J, Payne MR, Bartkova J, Lindström MS, Lukas J, Andersen JS, Bartek J, Larsen DH. Bennetzen MV, et al. Among authors: lindstrom ms. Cell Cycle. 2018;17(17):2146-2163. doi: 10.1080/15384101.2018.1515552. Epub 2018 Sep 22. Cell Cycle. 2018. PMID: 30196736 Free PMC article.
51 results