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Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead.
J Med Chem. 2024 Feb 22;67(4):2369-2378. doi: 10.1021/acs.jmedchem.3c01938. Epub 2024 Feb 9.
J Med Chem. 2024.
PMID: 38335279
Free PMC article.
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions.
Bakowski MA, Beutler N, Wolff KC, Kirkpatrick MG, Chen E, Nguyen TH, Riva L, Shaabani N, Parren M, Ricketts J, Gupta AK, Pan K, Kuo P, Fuller M, Garcia E, Teijaro JR, Yang L, Sahoo D, Chi V, Huang E, Vargas N, Roberts AJ, Das S, Ghosh P, Woods AK, Joseph SB, Hull MV, Schultz PG, Burton DR, Chatterjee AK, McNamara CW, Rogers TF.
Bakowski MA, et al. Among authors: wolff kc.
Nat Commun. 2021 Jun 3;12(1):3309. doi: 10.1038/s41467-021-23328-0.
Nat Commun. 2021.
PMID: 34083527
Free PMC article.
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Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication.
Garcia G Jr, Sharma A, Ramaiah A, Sen C, Purkayastha A, Kohn DB, Parcells MS, Beck S, Kim H, Bakowski MA, Kirkpatrick MG, Riva L, Wolff KC, Han B, Yuen C, Ulmert D, Purbey PK, Scumpia P, Beutler N, Rogers TF, Chatterjee AK, Gabriel G, Bartenschlager R, Gomperts B, Svendsen CN, Betz UAK, Damoiseaux RD, Arumugaswami V.
Garcia G Jr, et al. Among authors: wolff kc.
Cell Rep. 2021 Apr 6;35(1):108940. doi: 10.1016/j.celrep.2021.108940. Epub 2021 Mar 18.
Cell Rep. 2021.
PMID: 33784499
Free PMC article.
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Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling.
McAllister CS, Ansaldi D, Growcott EJ, Zhong Y, Quackenbush D, Wolff KC, Chen Z, Tanaseichuk O, Lelais G, Barnes SW, Federe GC, Luna F, Walker JR, Zhou Y, Kuhen KL.
McAllister CS, et al. Among authors: wolff kc.
Virology. 2020 Jan 15;540:195-206. doi: 10.1016/j.virol.2019.10.007. Epub 2019 Oct 23.
Virology. 2020.
PMID: 31929001
Free article.
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RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment.
Li Z, Wolff KC, Samuel CE.
Li Z, et al. Among authors: wolff kc.
Virology. 2010 Jan 20;396(2):316-22. doi: 10.1016/j.virol.2009.10.026. Epub 2009 Nov 12.
Virology. 2010.
PMID: 19913273
Free PMC article.
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Identification of novel therapeutic targets for HIV infection through functional genomic cDNA screening.
Nguyen DG, Yin H, Zhou Y, Wolff KC, Kuhen KL, Caldwell JS.
Nguyen DG, et al. Among authors: wolff kc.
Virology. 2007 May 25;362(1):16-25. doi: 10.1016/j.virol.2006.11.036. Epub 2007 Jan 25.
Virology. 2007.
PMID: 17257639
Free article.
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"UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infection.
Nguyen DG, Wolff KC, Yin H, Caldwell JS, Kuhen KL.
Nguyen DG, et al. Among authors: wolff kc.
J Virol. 2006 Jan;80(1):130-7. doi: 10.1128/JVI.80.1.130-137.2006.
J Virol. 2006.
PMID: 16352537
Free PMC article.
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Vaccinia virus E3L interferon resistance protein inhibits the interferon-induced adenosine deaminase A-to-I editing activity.
Liu Y, Wolff KC, Jacobs BL, Samuel CE.
Liu Y, et al. Among authors: wolff kc.
Virology. 2001 Oct 25;289(2):378-87. doi: 10.1006/viro.2001.1154.
Virology. 2001.
PMID: 11689059
Free article.
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