Plise E - Search Results

1

Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation.

Faris JH, Adaligil E, Popovych N, Ono S, Takahashi M, Nguyen H, Plise E, Taechalertpaisarn J, Lee HW, Koehler MFT, Cunningham CN, Lokey RS. Faris JH, et al. Among authors: plise e. J Am Chem Soc. 2024 Feb 21;146(7):4582-4591. doi: 10.1021/jacs.3c10949. Epub 2024 Feb 8. J Am Chem Soc. 2024. PMID: 38330910 Free PMC article.

2

An Integrated Strategy for Assessing the Metabolic Stability and Biotransformation of Macrocyclic Peptides in Drug Discovery toward Oral Delivery.

Guo Y, Ji S, Wang W, Wong S, Yen CW, Hu C, Leung DH, Plise E, Zhang S, Zhang C, Anene UA, Zhang D, Cunningham CN, Khojasteh SC, Su D. Guo Y, et al. Among authors: plise e. Anal Chem. 2022 Feb 1;94(4):2032-2041. doi: 10.1021/acs.analchem.1c04008. Epub 2022 Jan 18. Anal Chem. 2022. PMID: 35041378

3

Predicting Passive Permeability of Drug-like Molecules from Chemical Structure: Where Are We?

Broccatelli F, Salphati L, Plise E, Cheong J, Gobbi A, Lee ML, Aliagas I. Broccatelli F, et al. Among authors: plise e. Mol Pharm. 2016 Dec 5;13(12):4199-4208. doi: 10.1021/acs.molpharmaceut.6b00836. Epub 2016 Nov 11. Mol Pharm. 2016. PMID: 27806577

4

Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation.

Rosenberg SC, Shanahan F, Yamazoe S, Kschonsak M, Zeng YJ, Lee J, Plise E, Yen I, Rose CM, Quinn JG, Gazzard LJ, Walters BT, Kirkpatrick DS, Staben ST, Foster SA, Malek S. Rosenberg SC, et al. Among authors: plise e. Cell Chem Biol. 2023 Feb 8:S2451-9456(23)00030-2. doi: 10.1016/j.chembiol.2023.01.007. Online ahead of print. Cell Chem Biol. 2023. PMID: 36773603 Free article.

5

Turning the Other Cheek: Influence of the cis-Tetrafluorocyclohexyl Motif on Physicochemical and Metabolic Properties.

Wang Y, Lee W, Chen YC, Zhou Y, Plise E, Migliozzi M, Crawford JJ. Wang Y, et al. Among authors: plise e. ACS Med Chem Lett. 2022 Aug 14;13(9):1517-1523. doi: 10.1021/acsmedchemlett.2c00312. eCollection 2022 Sep 8. ACS Med Chem Lett. 2022. PMID: 36105337 Free PMC article.

6

Evaluation of bottom-up modeling of the blood-brain barrier to improve brain penetration prediction via physiologically based pharmacokinetic modeling.

Bowman C, Ma F, Mao J, Plise E, Chen E, Liu L, Zhang S, Chen Y. Bowman C, et al. Among authors: plise e. Biopharm Drug Dispos. 2023 Feb;44(1):60-70. doi: 10.1002/bdd.2344. Epub 2023 Feb 7. Biopharm Drug Dispos. 2023. PMID: 36630933

7

Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney I Cells in Permeability Screening and Efflux Substrate Determination.

Chen EC, Broccatelli F, Plise E, Chen B, Liu L, Cheong J, Zhang S, Jorski J, Gaffney K, Umemoto KK, Salphati L. Chen EC, et al. Among authors: plise e. Mol Pharm. 2018 Nov 5;15(11):5103-5113. doi: 10.1021/acs.molpharmaceut.8b00688. Epub 2018 Oct 10. Mol Pharm. 2018. PMID: 30222362

8

An Integrated Analysis of Solid Form Change Impact on Solubility and Permeability: Case Study of Oral Exposure in Rats of an RAR Related Orphan Receptor C Inhibitor.

Chiang PC, Nagapudi K, Liu J, Crawford JJ, Zbieg JR, Plise E, Deng Y. Chiang PC, et al. Among authors: plise e. J Pharm Sci. 2019 Jul;108(7):2256-2263. doi: 10.1016/j.xphs.2019.01.031. Epub 2019 Feb 7. J Pharm Sci. 2019. PMID: 30738851

9

Practical permeability-based hepatic clearance classification system (HepCCS) in drug discovery.

Fan PW, Song Y, Berezhkovskiy LM, Cheong J, Plise EG, Khojasteh SC. Fan PW, et al. Future Med Chem. 2014;6(18):1995-2012. doi: 10.4155/fmc.14.141. Future Med Chem. 2014. PMID: 25531965

10

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR.

Heffron TP, Ndubaku CO, Salphati L, Alicke B, Cheong J, Drobnick J, Edgar K, Gould SE, Lee LB, Lesnick JD, Lewis C, Nonomiya J, Pang J, Plise EG, Sideris S, Wallin J, Wang L, Zhang X, Olivero AG. Heffron TP, et al. Among authors: plise eg. ACS Med Chem Lett. 2016 Feb 16;7(4):351-6. doi: 10.1021/acsmedchemlett.6b00005. eCollection 2016 Apr 14. ACS Med Chem Lett. 2016. PMID: 27096040 Free PMC article.

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