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Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist.
Litvinchuk A, Suh JH, Guo JL, Lin K, Davis SS, Bien-Ly N, Tycksen E, Tabor GT, Serrano JR, Manis M, Bao X, Lee C, Bosch M, Perez EJ, Yuede CM, Cashikar AG, Ulrich JD, Di Paolo G, Holtzman DM. Litvinchuk A, et al. Among authors: tycksen e. Neuron. 2024 May 31:S0896-6273(24)00368-4. doi: 10.1016/j.neuron.2024.05.021. Online ahead of print. Neuron. 2024. PMID: 38823392 No abstract available.
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist.
Litvinchuk A, Suh JH, Guo JL, Lin K, Davis SS, Bien-Ly N, Tycksen E, Tabor GT, Remolina Serrano J, Manis M, Bao X, Lee C, Bosch M, Perez EJ, Yuede CM, Cashikar AG, Ulrich JD, Di Paolo G, Holtzman DM. Litvinchuk A, et al. Among authors: tycksen e. Neuron. 2024 Feb 7;112(3):384-403.e8. doi: 10.1016/j.neuron.2023.10.023. Epub 2023 Nov 22. Neuron. 2024. PMID: 37995685
MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice.
Kim Y, Li C, Gu C, Fang Y, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM. Kim Y, et al. Among authors: tycksen e. Nat Commun. 2023 Oct 14;14(1):6493. doi: 10.1038/s41467-023-42154-0. Nat Commun. 2023. PMID: 37838725 Free PMC article.
BAP1 promotes osteoclast function by metabolic reprogramming.
Rohatgi N, Zou W, Li Y, Cho K, Collins PL, Tycksen E, Pandey G, DeSelm CJ, Patti GJ, Dey A, Teitelbaum SL. Rohatgi N, et al. Among authors: tycksen e. Nat Commun. 2023 Sep 22;14(1):5923. doi: 10.1038/s41467-023-41629-4. Nat Commun. 2023. PMID: 37740028 Free PMC article.
Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice.
Parhizkar S, Gent G, Chen Y, Rensing N, Gratuze M, Strout G, Sviben S, Tycksen E, Zhang Q, Gilmore PE, Sprung R, Malone J, Chen W, Remolina Serrano J, Bao X, Lee C, Wang C, Landsness E, Fitzpatrick J, Wong M, Townsend R, Colonna M, Schmidt RE, Holtzman DM. Parhizkar S, et al. Among authors: tycksen e. Sci Transl Med. 2023 Apr 26;15(693):eade6285. doi: 10.1126/scitranslmed.ade6285. Epub 2023 Apr 26. Sci Transl Med. 2023. PMID: 37099634 Free PMC article.
MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy.
Kim Y, Li C, Gu C, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Fang Y, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM. Kim Y, et al. Among authors: tycksen e. bioRxiv [Preprint]. 2023 Jan 12:2023.01.10.523171. doi: 10.1101/2023.01.10.523171. bioRxiv. 2023. PMID: 36711449 Free PMC article. Updated. Preprint.
56 results