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Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development.
Christensen KE, Hou W, Bahous RH, Deng L, Malysheva OV, Arning E, Bottiglieri T, Caudill MA, Jerome-Majewska LA, Rozen R. Christensen KE, et al. Among authors: caudill ma. Am J Clin Nutr. 2016 Nov;104(5):1459-1469. doi: 10.3945/ajcn.116.139519. Epub 2016 Oct 5. Am J Clin Nutr. 2016. PMID: 27707701 Free article.
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