Geist B - Search Results

1

Trastuzumab-MMAU Antibody-Auristatin Conjugates: Valine-Glucoserine Linker with Stabilized Maleimide Conjugation Improves In Vivo Efficacy and Tolerability.

Goldberg SD, Satomaa T, Aina O, Aitio O, Burke K, Dudkin V, Geist B, Irrechukwu O, Hänninen AL, Heiskanen A, Helin J, Hiltunen JO, Kinyamu-Akunda J, Klein DM, Kohli N, Kotiranta T, Lähteenmäki T, Niemelä R, Pitkänen V, Pynnönen H, Rittase W, Wiley K, Zhou J, Saarinen J. Goldberg SD, et al. Among authors: geist b. Mol Cancer Ther. 2024 Feb 7. doi: 10.1158/1535-7163.MCT-23-0591. Online ahead of print. Mol Cancer Ther. 2024. PMID: 38324296

2

Development and Translational Application of a Minimal Physiologically Based Pharmacokinetic Model for a Monoclonal Antibody against Interleukin 23 (IL-23) in IL-23-Induced Psoriasis-Like Mice.

Chen X, Jiang X, Doddareddy R, Geist B, McIntosh T, Jusko WJ, Zhou H, Wang W. Chen X, et al. Among authors: geist b. J Pharmacol Exp Ther. 2018 Apr;365(1):140-155. doi: 10.1124/jpet.117.244855. Epub 2018 Feb 2. J Pharmacol Exp Ther. 2018. PMID: 29420255

3

Characterization of concurrent target suppression by JNJ-61178104, a bispecific antibody against human tumor necrosis factor and interleukin-17A.

Zheng S, Shen F, Jones B, Fink D, Geist B, Nnane I, Zhou Z, Hall J, Malaviya R, Ort T, Wang W. Zheng S, et al. Among authors: geist b. MAbs. 2020 Jan-Dec;12(1):1770018. doi: 10.1080/19420862.2020.1770018. MAbs. 2020. PMID: 32544369 Free PMC article.

4

A long-acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model.

Zheng S, Polidori D, Wang Y, Geist B, Lin-Schmidt X, Furman JL, Nelson S, Nawrocki AR, Hinke SA. Zheng S, et al. Among authors: geist b. Clin Transl Sci. 2023 Aug;16(8):1431-1444. doi: 10.1111/cts.13543. Epub 2023 May 23. Clin Transl Sci. 2023. PMID: 37154518 Free PMC article.

5

Enhanced delivery of antibodies across the blood-brain barrier via TEMs with inherent receptor-mediated phagocytosis.

Edavettal S, Cejudo-Martin P, Dasgupta B, Yang D, Buschman MD, Domingo D, Van Kolen K, Jaiprasat P, Gordon R, Schutsky K, Geist B, Taylor N, Soubrane CH, Van Der Helm E, LaCombe A, Ainekulu Z, Lacy E, Aligo J, Ho J, He Y, Lebowitz PF, Patterson JT, Scheer JM, Singh S. Edavettal S, et al. Among authors: geist b. Med. 2022 Dec 9;3(12):860-882.e15. doi: 10.1016/j.medj.2022.09.007. Epub 2022 Oct 17. Med. 2022. PMID: 36257298 Free article.

6

Application of multiplexed pharmacokinetic immunoassay to quantify in vivo drug forms and coadministered biologics.

Woodbury N, Bald E, Geist B, Yang TY. Woodbury N, et al. Among authors: geist b. Bioanalysis. 2019 Dec;11(24):2251-2268. doi: 10.4155/bio-2019-0147. Bioanalysis. 2019. PMID: 31845605 Free article.

7

Discovery and characterization of single-domain antibodies for polymeric Ig receptor-mediated mucosal delivery of biologics.

Maruthachalam BV, Zwolak A, Lin-Schmidt X, Keough E, Tamot N, Venkataramani S, Geist B, Singh S, Ganesan R. Maruthachalam BV, et al. Among authors: geist b. MAbs. 2020 Jan-Dec;12(1):1708030. doi: 10.1080/19420862.2019.1708030. MAbs. 2020. PMID: 31906797 Free PMC article.

8

A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model.

Zheng S, Niu J, Geist B, Fink D, Xu Z, Zhou H, Wang W. Zheng S, et al. Among authors: geist b. MAbs. 2020 Jan-Dec;12(1):1813962. doi: 10.1080/19420862.2020.1813962. MAbs. 2020. PMID: 32967523 Free PMC article.

9

Translational PK/PD and model-informed development of JNJ-67842125, a F_ab reversal agent for JNJ-64179375, a long-acting thrombin inhibitor.

Ayyar VS, Jaiprasart P, Geist B, Huang Devine Z, Case M, Hazra A, Hsu CH, Chintala M, Wang W. Ayyar VS, et al. Among authors: geist b. Br J Pharmacol. 2021 Oct;178(19):3943-3958. doi: 10.1111/bph.15533. Epub 2021 Jun 29. Br J Pharmacol. 2021. PMID: 34008170 Free article.

10

Bifunctional molecules targeting SARS-CoV-2 spike and the polymeric Ig receptor display neutralization activity and mucosal enrichment.

White I, Tamot N, Doddareddy R, Ho J, Jiao Q, Harvilla PB, Yang TY, Geist B, Borrok MJ, Truppo MD, Ganesan R, Chowdhury P, Zwolak A. White I, et al. Among authors: geist b. MAbs. 2021 Jan-Dec;13(1):1987180. doi: 10.1080/19420862.2021.1987180. MAbs. 2021. PMID: 34693867 Free PMC article.

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