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Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma.
Kim Y, Jung KY, Kim YH, Xu P, Kang BE, Jo Y, Pandit N, Kwon J, Gariani K, Gariani J, Lee J, Verbeek J, Nam S, Bae SJ, Ha KT, Yi HS, Shong M, Kim KH, Kim D, Jung HJ, Lee CW, Kim KR, Schoonjans K, Auwerx J, Ryu D. Kim Y, et al. Among authors: schoonjans k. Drug Resist Updat. 2024 Mar;73:101054. doi: 10.1016/j.drup.2024.101054. Epub 2024 Jan 17. Drug Resist Updat. 2024. PMID: 38277756 Free PMC article.
The metabolic footprint of aging in mice.
Houtkooper RH, Argmann C, Houten SM, Cantó C, Jeninga EH, Andreux PA, Thomas C, Doenlen R, Schoonjans K, Auwerx J. Houtkooper RH, et al. Among authors: schoonjans k. Sci Rep. 2011;1:134. doi: 10.1038/srep00134. Epub 2011 Oct 31. Sci Rep. 2011. PMID: 22355651 Free PMC article.
Metabolic characterization of a Sirt5 deficient mouse model.
Yu J, Sadhukhan S, Noriega LG, Moullan N, He B, Weiss RS, Lin H, Schoonjans K, Auwerx J. Yu J, et al. Among authors: schoonjans k. Sci Rep. 2013 Sep 30;3:2806. doi: 10.1038/srep02806. Sci Rep. 2013. PMID: 24076663 Free PMC article.
A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function.
Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J. Ryu D, et al. Among authors: schoonjans k. Cell Metab. 2014 Nov 4;20(5):856-869. doi: 10.1016/j.cmet.2014.08.001. Epub 2014 Sep 4. Cell Metab. 2014. PMID: 25200183 Free article.
Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice.
Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J. Gariani K, et al. Among authors: schoonjans k. Hepatology. 2016 Apr;63(4):1190-204. doi: 10.1002/hep.28245. Epub 2015 Dec 16. Hepatology. 2016. PMID: 26404765 Free PMC article.
Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease.
Gariani K, Ryu D, Menzies KJ, Yi HS, Stein S, Zhang H, Perino A, Lemos V, Katsyuba E, Jha P, Vijgen S, Rubbia-Brandt L, Kim YK, Kim JT, Kim KS, Shong M, Schoonjans K, Auwerx J. Gariani K, et al. Among authors: schoonjans k. J Hepatol. 2017 Jan;66(1):132-141. doi: 10.1016/j.jhep.2016.08.024. Epub 2016 Sep 20. J Hepatol. 2017. PMID: 27663419 Free article.
De novo NAD+ synthesis enhances mitochondrial function and improves health.
Katsyuba E, Mottis A, Zietak M, De Franco F, van der Velpen V, Gariani K, Ryu D, Cialabrini L, Matilainen O, Liscio P, Giacchè N, Stokar-Regenscheit N, Legouis D, de Seigneux S, Ivanisevic J, Raffaelli N, Schoonjans K, Pellicciari R, Auwerx J. Katsyuba E, et al. Among authors: schoonjans k. Nature. 2018 Nov;563(7731):354-359. doi: 10.1038/s41586-018-0645-6. Epub 2018 Oct 24. Nature. 2018. PMID: 30356218 Free PMC article.
194 results