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Molecular Mechanisms of Amyloid-β Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone.
Kumar R, Arroyo-García LE, Manchanda S, Adam L, Pizzirusso G, Biverstål H, Nilsson P, Fisahn A, Johansson J, Abelein A. Kumar R, et al. Among authors: biverstal h. ACS Chem Neurosci. 2023 Apr 6;14(8):1503-11. doi: 10.1021/acschemneuro.3c00044. Online ahead of print. ACS Chem Neurosci. 2023. PMID: 37023330 Free PMC article.
Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue.
Chen G, Andrade-Talavera Y, Zhong X, Hassan S, Biverstål H, Poska H, Abelein A, Leppert A, Kronqvist N, Rising A, Hebert H, Koeck PJB, Fisahn A, Johansson J. Chen G, et al. Among authors: biverstal h. RSC Chem Biol. 2022 Sep 15;3(11):1342-1358. doi: 10.1039/d2cb00187j. eCollection 2022 Nov 2. RSC Chem Biol. 2022. PMID: 36349220 Free PMC article.
Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation.
Nagaraj M, Najarzadeh Z, Pansieri J, Biverstål H, Musteikyte G, Smirnovas V, Matthews S, Emanuelsson C, Johansson J, Buxbaum JN, Morozova-Roche L, Otzen DE. Nagaraj M, et al. Among authors: biverstal h. Chem Sci. 2021 Dec 13;13(2):536-553. doi: 10.1039/d1sc05790a. eCollection 2022 Jan 5. Chem Sci. 2021. PMID: 35126986 Free PMC article.
30 results