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Isoform-selective TGF-β3 inhibition for systemic sclerosis.
Sun T, Vander Heiden JA, Gao X, Yin J, Uttarwar S, Liang WC, Jia G, Yadav R, Huang Z, Mitra M, Halpern W, Bender HS, Brightbill HD, Wu Y, Lupardus P, Ramalingam T, Arron JR. Sun T, et al. Among authors: halpern w. Med. 2024 Feb 9;5(2):132-147.e7. doi: 10.1016/j.medj.2023.12.011. Epub 2024 Jan 24. Med. 2024. PMID: 38272035 Free article.
Preclinical and translational pharmacology of afucosylated anti-CCR8 antibody for depletion of tumour-infiltrating regulatory T cells.
Gampa G, Spinosa P, Getz J, Zhong Y, Halpern W, Esen E, Davies J, Chou C, Kwong M, Wang Y, Arenzana TL, Shivva V, Huseni M, Hsieh R, Schartner J, Koerber JT, Rutz S, Hosseini I. Gampa G, et al. Among authors: halpern w. Br J Pharmacol. 2024 Mar 14. doi: 10.1111/bph.16326. Online ahead of print. Br J Pharmacol. 2024. PMID: 38486310
Stems to GEMs: impact of stem cell technology on engineered animal models.
Halpern W, McArthur M, Galbreath E, Uhl E, Buck W, Whitley E; American College of Veterinary Pathologists Intersociety Experimental Pathology Committee. Halpern W, et al. Vet Pathol. 2011 Sep;48(5):1041-3. doi: 10.1177/0300985811413093. Vet Pathol. 2011. PMID: 21865606
Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for the Treatment of Fibrotic Diseases.
Yadav R, Sukumaran S, Lutman J, Mitra MS, Halpern W, Sun T, Setiadi AF, Neighbors M, Sheng XR, Yip V, Shen BQ, Liu C, Han L, Ovacik AM, Wu Y, Glickstein S, Kunder R, Arron JR, Pan L, Kamath AV, Stefanich EG. Yadav R, et al. Among authors: halpern w. J Pharm Sci. 2023 Nov;112(11):2910-2920. doi: 10.1016/j.xphs.2023.07.005. Epub 2023 Jul 8. J Pharm Sci. 2023. PMID: 37429356 Free article.
FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations.
Ackley D, Birkebak J, Blumel J, Bourcier T, de Zafra C, Goodwin A, Halpern W, Herzyk D, Kronenberg S, Mauthe R, Shenton J, Shuey D, Wange RL. Ackley D, et al. Among authors: halpern w. Regul Toxicol Pharmacol. 2023 Feb;138:105327. doi: 10.1016/j.yrtph.2022.105327. Epub 2022 Dec 28. Regul Toxicol Pharmacol. 2023. PMID: 36586472 Free article.
Surfactant protein D is a biomarker of influenza-related pediatric lung injury.
Chakrabarti A, Nguyen A, Newhams MM, Ohlson MB, Yang X, Ulufatu S, Liu S, Park S, Xu M, Jiang J, Halpern WG, Anania VG, McBride JM, Rosenberger CM, Randolph AG; Pediatric Intensive Care Influenza (PICFLU) Investigators. Chakrabarti A, et al. Among authors: halpern wg. Pediatr Pulmonol. 2022 Feb;57(2):519-528. doi: 10.1002/ppul.25776. Epub 2021 Dec 7. Pediatr Pulmonol. 2022. PMID: 34842360 Free PMC article.
88 results