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AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5.
Feracci M, Eydoux C, Fattorini V, Lo Bello L, Gauffre P, Selisko B, Sutto-Ortiz P, Shannon A, Xia H, Shi PY, Noel M, Debart F, Vasseur JJ, Good S, Lin K, Moussa A, Sommadossi JP, Chazot A, Alvarez K, Guillemot JC, Decroly E, Ferron F, Canard B. Feracci M, et al. Among authors: sommadossi jp. Antiviral Res. 2023 Apr;212:105574. doi: 10.1016/j.antiviral.2023.105574. Epub 2023 Mar 9. Antiviral Res. 2023. PMID: 36905944
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.
Shannon A, Fattorini V, Sama B, Selisko B, Feracci M, Falcou C, Gauffre P, El Kazzi P, Delpal A, Decroly E, Alvarez K, Eydoux C, Guillemot JC, Moussa A, Good SS, La Colla P, Lin K, Sommadossi JP, Zhu Y, Yan X, Shi H, Ferron F, Canard B. Shannon A, et al. Among authors: sommadossi jp. Nat Commun. 2022 Feb 2;13(1):621. doi: 10.1038/s41467-022-28113-1. Nat Commun. 2022. PMID: 35110538 Free PMC article.
Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with In Vitro and In Vivo Activity against Dengue and Other Flaviviruses.
Good SS, Shannon A, Lin K, Moussa A, Julander JG, La Colla P, Collu G, Canard B, Sommadossi JP. Good SS, et al. Among authors: sommadossi jp. Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0098821. doi: 10.1128/AAC.00988-21. Epub 2021 Aug 23. Antimicrob Agents Chemother. 2021. PMID: 34424050 Free PMC article.
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19.
Good SS, Westover J, Jung KH, Zhou XJ, Moussa A, La Colla P, Collu G, Canard B, Sommadossi JP. Good SS, et al. Among authors: sommadossi jp. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02479-20. doi: 10.1128/AAC.02479-20. Print 2021 Mar 18. Antimicrob Agents Chemother. 2021. PMID: 33558299 Free PMC article.
Author Correction: Supporting US public health experts.
Cohen R, Francois C, Crowley J, Hastings P, King R, Love TW, Maraganore J, McMurry-Heath M, Levin J; Cosignatories. Cohen R, et al. Nat Biotechnol. 2021 Jan;39(1):115. doi: 10.1038/s41587-020-00792-5. Nat Biotechnol. 2021. PMID: 33335308 No abstract available.
Supporting US public health experts.
Cohen R, Francois C, Crowley J, Hastings P, King R, Love TW, Maraganore J, McMurry-Heath M, Levin J; Cosignatories. Cohen R, et al. Nat Biotechnol. 2020 Dec;38(12):1381-1384. doi: 10.1038/s41587-020-00767-6. Nat Biotechnol. 2020. PMID: 33239766 No abstract available.
168 results