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Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer.
Hosseini A, Lindholm HT, Chen R, Mehdipour P, Marhon SA, Ishak CA, Moore PC, Classon M, Di Gioacchino A, Greenbaum B, De Carvalho DD. Hosseini A, et al. Among authors: ishak ca. Cell Rep. 2024 Feb 27;43(2):113684. doi: 10.1016/j.celrep.2024.113684. Epub 2024 Jan 22. Cell Rep. 2024. PMID: 38261511 Free article.
Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency.
Mehdipour P, Marhon SA, Ettayebi I, Chakravarthy A, Hosseini A, Wang Y, de Castro FA, Loo Yau H, Ishak C, Abelson S, O'Brien CA, De Carvalho DD. Mehdipour P, et al. Among authors: ishak c. Nature. 2020 Dec;588(7836):169-173. doi: 10.1038/s41586-020-2844-1. Epub 2020 Oct 21. Nature. 2020. PMID: 33087935
DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells.
Loo Yau H, Bell E, Ettayebi I, de Almeida FC, Boukhaled GM, Shen SY, Allard D, Morancho B, Marhon SA, Ishak CA, Gonzaga IM, da Silva Medina T, Singhania R, Chakravarthy A, Chen R, Mehdipour P, Pommey S, Klein C, Amarante-Mendes GP, Roulois D, Arribas J, Stagg J, Brooks DG, De Carvalho DD. Loo Yau H, et al. Among authors: ishak ca. Mol Cell. 2021 Apr 1;81(7):1469-1483.e8. doi: 10.1016/j.molcel.2021.01.038. Epub 2021 Feb 19. Mol Cell. 2021. PMID: 33609448 Free article.
An open-label, phase II multicohort study of an oral hypomethylating agent CC-486 and durvalumab in advanced solid tumors.
Taylor K, Loo Yau H, Chakravarthy A, Wang B, Shen SY, Ettayebi I, Ishak CA, Bedard PL, Abdul Razak A, R Hansen A, Spreafico A, Cescon D, Butler MO, Oza AM, Lheureux S, Stjepanovic N, Van As B, Boross-Harmer S, Wang L, Pugh TJ, Ohashi PS, Siu LL, De Carvalho DD. Taylor K, et al. Among authors: ishak ca. J Immunother Cancer. 2020 Aug;8(2):e000883. doi: 10.1136/jitc-2020-000883. J Immunother Cancer. 2020. PMID: 32753546 Free PMC article. Clinical Trial.
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