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Physiologically based pharmacokinetic modeling to predict the impact of liver cirrhosis on glucuronidation via UGT1A4 & UGT2B7/2B4 - a case study with midazolam.
Drug Metab Dispos. 2024 Apr 23:DMD-AR-2023-001635. doi: 10.1124/dmd.123.001635. Online ahead of print.
Drug Metab Dispos. 2024.
PMID: 38653501
Free article.
Metabolic drives affecting Th17/Treg gene expression changes and differentiation: impact on immune-microenvironment regulation.
Brescia C, Audia S, Pugliano A, Scaglione F, Iuliano R, Trapasso F, Perrotti N, Chiarella E, Amato R.
Brescia C, et al. Among authors: pugliano a.
APMIS. 2024 Jan 18. doi: 10.1111/apm.13378. Online ahead of print.
APMIS. 2024.
PMID: 38239016
Review.
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Quantitative Cytochrome P450 3A4 Induction Risk Assessment Using Human Hepatocytes Complemented with Pregnane X Receptor-Activating Profiles.
Ekiciler A, Chen WLK, Bo Y, Pugliano A, Donzelli M, Parrott N, Umehara K.
Ekiciler A, et al. Among authors: pugliano a.
Drug Metab Dispos. 2023 Mar;51(3):276-284. doi: 10.1124/dmd.122.001132. Epub 2022 Dec 2.
Drug Metab Dispos. 2023.
PMID: 36460477
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