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Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase.
Zmudzinski M, Rut W, Olech K, Granda J, Giurg M, Burda-Grabowska M, Kaleta R, Zgarbova M, Kasprzyk R, Zhang L, Sun X, Lv Z, Nayak D, Kesik-Brodacka M, Olsen SK, Weber J, Hilgenfeld R, Jemielity J, Drag M. Zmudzinski M, et al. Among authors: kasprzyk r. Sci Rep. 2023 Jun 6;13(1):9161. doi: 10.1038/s41598-023-35907-w. Sci Rep. 2023. PMID: 37280236 Free PMC article.
2'-O-Methylation of the second transcribed nucleotide within the mRNA 5' cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion.
Drazkowska K, Tomecki R, Warminski M, Baran N, Cysewski D, Depaix A, Kasprzyk R, Kowalska J, Jemielity J, Sikorski PJ. Drazkowska K, et al. Among authors: kasprzyk r. Nucleic Acids Res. 2022 Sep 9;50(16):9051-9071. doi: 10.1093/nar/gkac722. Nucleic Acids Res. 2022. PMID: 36018811 Free PMC article.
Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications.
Kleczewska N, Sikorski PJ, Warminska Z, Markiewicz L, Kasprzyk R, Baran N, Kwapiszewska K, Karpinska A, Michalski J, Holyst R, Kowalska J, Jemielity J. Kleczewska N, et al. Among authors: kasprzyk r. Chem Sci. 2021 Jun 29;12(30):10242-10251. doi: 10.1039/d1sc02143e. eCollection 2021 Aug 4. Chem Sci. 2021. PMID: 34377411 Free PMC article.
Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect.
Warminski M, Kowalska J, Nowak E, Kubacka D, Tibble R, Kasprzyk R, Sikorski PJ, Gross JD, Nowotny M, Jemielity J. Warminski M, et al. Among authors: kasprzyk r. ACS Chem Biol. 2021 Feb 19;16(2):334-343. doi: 10.1021/acschembio.0c00864. Epub 2021 Jan 13. ACS Chem Biol. 2021. PMID: 33439620 Free PMC article.
21 results