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Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.
Crespo-Garcia S, Fournier F, Diaz-Marin R, Klier S, Ragusa D, Masaki L, Cagnone G, Blot G, Hafiane I, Dejda A, Rizk R, Juneau R, Buscarlet M, Chorfi S, Patel P, Beltran PJ, Joyal JS, Rezende FA, Hata M, Nguyen A, Sullivan L, Damiano J, Wilson AM, Mallette FA, David NE, Ghosh A, Tsuruda PR, Dananberg J, Sapieha P. Crespo-Garcia S, et al. Nat Med. 2024 Feb;30(2):443-454. doi: 10.1038/s41591-024-02802-4. Epub 2024 Feb 6. Nat Med. 2024. PMID: 38321220 Clinical Trial.
Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration.
Roubeix C, Nous C, Augustin S, Ronning KE, Mathis T, Blond F, Lagouge-Roussey P, Crespo-Garcia S, Sullivan PM, Gautier EL, Reichhart N, Sahel JA, Burns ME, Paques M, Sørensen TL, Strauss O, Guillonneau X, Delarasse C, Sennlaub F. Roubeix C, et al. Among authors: crespo garcia s. J Neuroinflammation. 2024 Jan 17;21(1):22. doi: 10.1186/s12974-024-03011-z. J Neuroinflammation. 2024. PMID: 38233865 Free PMC article.
HIF1α-dependent hypoxia response in myeloid cells requires IRE1α.
Mawambo G, Oubaha M, Ichiyama Y, Blot G, Crespo-Garcia S, Dejda A, Binet F, Diaz-Marin R, Sawchyn C, Sergeev M, Juneau R, Kaufman RJ, Affar EB, Mallette FA, Wilson AM, Sapieha P. Mawambo G, et al. Among authors: crespo garcia s. J Neuroinflammation. 2023 Jun 21;20(1):145. doi: 10.1186/s12974-023-02793-y. J Neuroinflammation. 2023. PMID: 37344842 Free PMC article.
Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life.
Hata M, Hata M, Andriessen EM, Juneau R, Pilon F, Crespo-Garcia S, Diaz-Marin R, Guber V, Binet F, Fournier F, Buscarlet M, Grou C, Calderon V, Heckel E, Melichar HJ, Joyal JS, Wilson AM, Sapieha P. Hata M, et al. Among authors: crespo garcia s. J Clin Invest. 2023 Feb 15;133(4):e159757. doi: 10.1172/JCI159757. J Clin Invest. 2023. PMID: 36787231 Free PMC article.
Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation.
Hata M, Andriessen EMMA, Hata M, Diaz-Marin R, Fournier F, Crespo-Garcia S, Blot G, Juneau R, Pilon F, Dejda A, Guber V, Heckel E, Daneault C, Calderon V, Des Rosiers C, Melichar HJ, Langmann T, Joyal JS, Wilson AM, Sapieha P. Hata M, et al. Among authors: crespo garcia s. Science. 2023 Jan 6;379(6627):45-62. doi: 10.1126/science.abj8894. Epub 2023 Jan 5. Science. 2023. PMID: 36603072
Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity.
Diaz-Marin R, Crespo-Garcia S, Wilson AM, Buscarlet M, Dejda A, Fournier F, Juneau R, Alquier T, Sapieha P. Diaz-Marin R, et al. Among authors: crespo garcia s. Sci Rep. 2021 Aug 3;11(1):15767. doi: 10.1038/s41598-021-95064-w. Sci Rep. 2021. PMID: 34344941 Free PMC article.
Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy.
Crespo-Garcia S, Reichhart N, Kociok N, Skosyrski S, Joussen AM. Crespo-Garcia S, et al. Int J Mol Sci. 2021 Apr 25;22(9):4481. doi: 10.3390/ijms22094481. Int J Mol Sci. 2021. PMID: 33923095 Free PMC article.
Myeloid-resident neuropilin-1 promotes choroidal neovascularization while mitigating inflammation.
Andriessen EMMA, Binet F, Fournier F, Hata M, Dejda A, Mawambo G, Crespo-Garcia S, Pilon F, Buscarlet M, Beauchemin K, Bougie V, Cumberlidge G, Wilson AM, Bourgault S, Rezende FA, Beaulieu N, Delisle JS, Sapieha P. Andriessen EMMA, et al. Among authors: crespo garcia s. EMBO Mol Med. 2021 May 7;13(5):e11754. doi: 10.15252/emmm.201911754. Epub 2021 Apr 19. EMBO Mol Med. 2021. PMID: 33876574 Free PMC article.
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.
Crespo-Garcia S, Tsuruda PR, Dejda A, Ryan RD, Fournier F, Chaney SY, Pilon F, Dogan T, Cagnone G, Patel P, Buscarlet M, Dasgupta S, Girouard G, Rao SR, Wilson AM, O'Brien R, Juneau R, Guber V, Dubrac A, Beausejour C, Armstrong S, Mallette FA, Yohn CB, Joyal JS, Marquess D, Beltran PJ, Sapieha P. Crespo-Garcia S, et al. Cell Metab. 2021 Apr 6;33(4):818-832.e7. doi: 10.1016/j.cmet.2021.01.011. Epub 2021 Feb 5. Cell Metab. 2021. PMID: 33548171 Free article.
31 results