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Machine Learning-assisted immunophenotyping of peripheral blood identifies innate immune cells as best predictor of response to induction chemo-immunotherapy in head and neck squamous cell carcinoma - knowledge obtained from the CheckRad-CD8 trial.
Hecht M, Frey B, Gaipl US, Tianyu X, Eckstein M, Donaubauer AJ, Klautke G, Illmer T, Fleischmann M, Laban S, Hautmann MG, Tamaskovics B, Brunner TB, Becker I, Zhou JG, Hartmann A, Fietkau R, Iro H, Döllinger M, Gostian AO, Kist AM. Hecht M, et al. Neoplasia. 2024 Mar;49:100953. doi: 10.1016/j.neo.2023.100953. Epub 2024 Jan 16. Neoplasia. 2024. PMID: 38232493 Free PMC article.
Induction chemoimmunotherapy followed by CD8+ immune cell-based patient selection for chemotherapy-free radioimmunotherapy in locally advanced head and neck cancer.
Hecht M, Eckstein M, Rutzner S, von der Grün J, Illmer T, Klautke G, Laban S, Hautmann MG, Brunner TB, Tamaskovics B, Hinke A, Zhou JG, Frey B, Donaubauer AJ, Becker I, Semrau S, Hartmann A, Balermpas P, Budach W, Gaipl US, Iro H, Gostian AO, Fietkau R. Hecht M, et al. J Immunother Cancer. 2022 Jan;10(1):e003747. doi: 10.1136/jitc-2021-003747. J Immunother Cancer. 2022. PMID: 35078923 Free PMC article. Clinical Trial.
Identification and characterization of circular RNAs as novel putative biomarkers to predict anti-PD-1 monotherapy response in metastatic melanoma patients - Knowledge from two independent international studies.
Zhou JG, Liang R, Wang HT, Jin SH, Hu W, Frey B, Fietkau R, Hecht M, Ma H, Gaipl US. Zhou JG, et al. Among authors: hecht m. Neoplasia. 2023 Mar;37:100877. doi: 10.1016/j.neo.2023.100877. Epub 2023 Jan 23. Neoplasia. 2023. PMID: 36696838 Free PMC article.
Radiotherapy combined with docetaxel alters the immune phenotype of HNSCC cells and results in increased surface expression of CD137 and release of HMGB1 of specifically HPV-positive tumor cells.
Grottker F, Gehre S, Reichardt CM, Sengedorj A, Jost T, Rieckmann T, Hecht M, Gostian AO, Frey B, Fietkau R, Gaipl US, Rückert M. Grottker F, et al. Among authors: hecht m. Neoplasia. 2023 Nov;45:100944. doi: 10.1016/j.neo.2023.100944. Epub 2023 Oct 17. Neoplasia. 2023. PMID: 37857049 Free PMC article.
Safety and efficacy of single cycle induction treatment with cisplatin/docetaxel/ durvalumab/tremelimumab in locally advanced HNSCC: first results of CheckRad-CD8.
Hecht M, Gostian AO, Eckstein M, Rutzner S, von der Grün J, Illmer T, Hautmann MG, Klautke G, Laban S, Brunner T, Hinke A, Becker I, Frey B, Semrau S, Geppert CI, Hartmann A, Balermpas P, Budach W, Gaipl US, Iro H, Fietkau R. Hecht M, et al. J Immunother Cancer. 2020 Oct;8(2):e001378. doi: 10.1136/jitc-2020-001378. J Immunother Cancer. 2020. PMID: 33023982 Free PMC article.
Prospective evaluation of the prognostic value of immune-related adverse events in patients with non-melanoma solid tumour treated with PD-1/PD-L1 inhibitors alone and in combination with radiotherapy.
Schweizer C, Schubert P, Rutzner S, Eckstein M, Haderlein M, Lettmaier S, Semrau S, Gostian AO, Frey B, Gaipl US, Zhou JG, Fietkau R, Hecht M. Schweizer C, et al. Among authors: hecht m. Eur J Cancer. 2020 Nov;140:55-62. doi: 10.1016/j.ejca.2020.09.001. Epub 2020 Oct 9. Eur J Cancer. 2020. PMID: 33045663 Clinical Trial.
Prospective development and validation of a liquid immune profile-based signature (LIPS) to predict response of patients with recurrent/metastatic cancer to immune checkpoint inhibitors.
Zhou JG, Donaubauer AJ, Frey B, Becker I, Rutzner S, Eckstein M, Sun R, Ma H, Schubert P, Schweizer C, Fietkau R, Deutsch E, Gaipl U, Hecht M. Zhou JG, et al. Among authors: hecht m. J Immunother Cancer. 2021 Feb;9(2):e001845. doi: 10.1136/jitc-2020-001845. J Immunother Cancer. 2021. PMID: 33593828 Free PMC article.
Implementation of Double Immune Checkpoint Blockade Increases Response Rate to Induction Chemotherapy in Head and Neck Cancer.
Semrau S, Gostian AO, Traxdorf M, Eckstein M, Rutzner S, von der Grün J, Illmer T, Hautmann M, Klautke G, Laban S, Brunner T, Tamaskovics B, Frey B, Zhou JG, Geppert CI, Hartmann A, Balermpas P, Budach W, Gaipl U, Iro H, Fietkau R, Hecht M. Semrau S, et al. Among authors: hecht m. Cancers (Basel). 2021 Apr 19;13(8):1959. doi: 10.3390/cancers13081959. Cancers (Basel). 2021. PMID: 33921668 Free PMC article.
Hypofractionated Radiotherapy Upregulates Several Immune Checkpoint Molecules in Head and Neck Squamous Cell Carcinoma Cells Independently of the HPV Status While ICOS-L Is Upregulated Only on HPV-Positive Cells.
Wimmer S, Deloch L, Hader M, Derer A, Grottker F, Weissmann T, Hecht M, Gostian AO, Fietkau R, Frey B, Gaipl US. Wimmer S, et al. Among authors: hecht m. Int J Mol Sci. 2021 Aug 24;22(17):9114. doi: 10.3390/ijms22179114. Int J Mol Sci. 2021. PMID: 34502022 Free PMC article.
Reduction of Elective Radiotherapy Treatment Volume in Definitive Treatment of Locally Advanced Head and Neck Cancer-Comparison of a Prospective Trial with a Revised Simulated Contouring Approach.
Weissmann T, Speer S, Putz F, Lettmaier S, Schubert P, Shariff M, Semrau S, Gostian AO, Traxdorf M, Mueller SK, Eckstein M, Hautmann M, von der Grün J, Haderlein M, Frey B, Gaipl US, Bert C, Iro H, Fietkau R, Hecht M. Weissmann T, et al. Among authors: hecht m. J Clin Med. 2021 Oct 11;10(20):4653. doi: 10.3390/jcm10204653. J Clin Med. 2021. PMID: 34682782 Free PMC article.
593 results