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Structural Analogs of the GABAkine KRM-II-81 Are Orally Bioavailable Anticonvulsants without Sedation.
Pandey KP, Divović B, Rashid F, Golani LK, Cerne R, Zahn NM, Meyer MJ, Arnold LA, Sharmin D, Mian MY, Smith JL, Ping X, Jin X, Lippa A, Tiruveedhula VVNPB, Cook JM, Savić MM, Witkin JM. Pandey KP, et al. Among authors: cook jm. J Pharmacol Exp Ther. 2023 Apr;385(1):50-61. doi: 10.1124/jpet.122.001362. Epub 2023 Feb 6. J Pharmacol Exp Ther. 2023. PMID: 36746611 Free PMC article.
Comparative anticonvulsant activity of the GABAkine KRM-II-81 and a deuterated analog.
Ping X, Meyer MJ, Zahn NM, Golani LK, Sharmin D, Pandey KP, Revanian S, Mondal P, Jin X, Arnold LA, Cerne R, Cook JM, Divović B, Savić MM, Lippa A, Smith JL, Witkin JM. Ping X, et al. Among authors: cook jm. Drug Dev Res. 2023 May;84(3):527-531. doi: 10.1002/ddr.22042. Epub 2023 Feb 7. Drug Dev Res. 2023. PMID: 36748904
Therapeutic effects of KRM-II-81, positive allosteric modulator for α2/3 subunit containing GABAA receptors, in a mouse model of Dravet syndrome.
Nakakubo S, Hiramatsu Y, Goto T, Kimura S, Narugami M, Nakajima M, Ueda Y, Shiraishi H, Manabe A, Sharmin D, Cook JM, Egawa K. Nakakubo S, et al. Among authors: cook jm. Front Pharmacol. 2023 Oct 2;14:1273633. doi: 10.3389/fphar.2023.1273633. eCollection 2023. Front Pharmacol. 2023. PMID: 37849734 Free PMC article.
Development and validation of an LC-MS/MS method for the determination of ARN14988, an acid ceramidase inhibitor, and its application to a pharmacokinetic study in a mouse model.
Rajaratnam V, Islam MM, Kub EF, Rajaratnam S, Kim KB, Rahman MT, Rashid F, Benko AM, Cook JM, Arnold LA, Mirza SP. Rajaratnam V, et al. Among authors: cook jm. Biomed Chromatogr. 2024 Jan;38(1):e5754. doi: 10.1002/bmc.5754. Epub 2023 Sep 26. Biomed Chromatogr. 2024. PMID: 37750452
eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures.
Heise C, Taha E, Murru L, Ponzoni L, Cattaneo A, Guarnieri FC, Montani C, Mossa A, Vezzoli E, Ippolito G, Zapata J, Barrera I, Ryazanov AG, Cook J, Poe M, Stephen MR, Kopanitsa M, Benfante R, Rusconi F, Braida D, Francolini M, Proud CG, Valtorta F, Passafaro M, Sala M, Bachi A, Verpelli C, Rosenblum K, Sala C. Heise C, et al. Cereb Cortex. 2017 Mar 1;27(3):2226-2248. doi: 10.1093/cercor/bhw075. Cereb Cortex. 2017. PMID: 27005990 Free PMC article.
614 results