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INOVATYON/ ENGOT-ov5 study: Randomized phase III international study comparing trabectedin/pegylated liposomal doxorubicin (PLD) followed by platinum at progression vs carboplatin/PLD in patients with recurrent ovarian cancer progressing within 6-12 months after last platinum line.
Colombo N, Gadducci A, Sehouli J, Rulli E, Mäenpää J, Sessa C, Montes A, Ottevanger NB, Berger R, Vergote I, D'Incalci M, Churruca Galaz C, Chekerov R, Nyvang GB, Riniker S, Herbertson R, Fossati R, Barretina-Ginesta MP, Deryal M, Mirza MR, Biagioli E, Iglesias M, Funari G, Romeo M, Tasca G, Pardo B, Tognon G, Rubio-Pérez MJ, DeCensi A, De Giorgi U, Zola P, Benedetti Panici P, Aglietta M, Arcangeli V, Zamagni C, Bologna A, Westermann A, Heinzelmann-Schwarz V, Tsibulak I, Wimberger P, Poveda A; INOVATYON study group. Colombo N, et al. Br J Cancer. 2023 Apr;128(8):1503-1513. doi: 10.1038/s41416-022-02108-7. Epub 2023 Feb 9. Br J Cancer. 2023. PMID: 36759720 Free PMC article. Clinical Trial.
Trial of Anti-BDCA2 Antibody Litifilimab for Systemic Lupus Erythematosus.
Furie RA, van Vollenhoven RF, Kalunian K, Navarra S, Romero-Diaz J, Werth VP, Huang X, Clark G, Carroll H, Meyers A, Musselli C, Barbey C, Franchimont N; LILAC Trial Investigators. Furie RA, et al. N Engl J Med. 2022 Sep 8;387(10):894-904. doi: 10.1056/NEJMoa2118025. N Engl J Med. 2022. PMID: 36069871 Clinical Trial.
Trial of Anti-BDCA2 Antibody Litifilimab for Cutaneous Lupus Erythematosus.
Werth VP, Furie RA, Romero-Diaz J, Navarra S, Kalunian K, van Vollenhoven RF, Nyberg F, Kaffenberger BH, Sheikh SZ, Radunovic G, Huang X, Clark G, Carroll H, Naik H, Gaudreault F, Meyers A, Barbey C, Musselli C, Franchimont N; LILAC Trial Investigators. Werth VP, et al. N Engl J Med. 2022 Jul 28;387(4):321-331. doi: 10.1056/NEJMoa2118024. N Engl J Med. 2022. PMID: 35939578 Clinical Trial.
Different profiles of advanced heart failure among patients with and without diabetes mellitus. Findings from the EPICTER study.
Lorido JCA, Gómez JC, Correa MR, Iglesias JR, Fernández TC, Camajuncosa RJ, Izquierdo MC, Guardiola CJ, Pardo LF, Ruiz EP, Formiga F, Bautista PS. Lorido JCA, et al. Eur J Intern Med. 2022 Oct;104:59-65. doi: 10.1016/j.ejim.2022.07.014. Epub 2022 Jul 22. Eur J Intern Med. 2022. PMID: 35879216 Free article.
To analyze the importance of variables, we grew a random forest algorithm (RF) based on mortality at six months. RESULTS: A total of 3153 patients were included. ...The variables that were significantly related to mortality were the number of comorbidities (p=0.005) and sy …
To analyze the importance of variables, we grew a random forest algorithm (RF) based on mortality at six months. RESULTS: A total of …
Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU.
Riestra S, Taxonera C, Zabana Y, Carpio D, Chaparro M, Barrio J, Rivero M, López-Sanroman A, Esteve M, de Francisco R, Bastida G, García-López S, Mañosa M, Martin-Arranz MD, Pérez-Calle JL, Guardiola J, Muñoz F, Arranz L, Cabriada JL, García-Sepulcre MF, Navarro M, Montoro-Huguet MÁ, Ricart E, Bermejo F, Calvet X, Piqueras M, Garcia-Planella E, Márquez L, Mínguez M, Van Domselar M, Bujanda L, Aldeguer X, Sicilia B, Iglesias E, Alcaín G, Pérez-Martínez I, Rolle V, Castaño-García A, P Gisbert J, Domènech E, On Behalf Of The Eneida Registry From Geteccu. Riestra S, et al. J Clin Med. 2022 Jul 5;11(13):3915. doi: 10.3390/jcm11133915. J Clin Med. 2022. PMID: 35807201 Free PMC article.
Whole-genome sequencing reveals host factors underlying critical COVID-19.
Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P, Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch C, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Baras A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M, Rader DJ, Ritchie MD, Verma A, Fowler TA, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Elliott P, Walsh T, Tenesa A; GenOMICC investigators; 23andMe investigators; COVID-19 Human Genetics Initiative; Fawkes A, Murphy L, Rowan K, Ponting CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry SC, Moutsianas L, Law A, Caulfield MJ, Baillie JK. Kousathanas A, et al. Nature. 2022 Jul;607(7917):97-103. doi: 10.1038/s41586-022-04576-6. Epub 2022 Mar 7. Nature. 2022. PMID: 35255492 Free PMC article.
Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients.
Gutiérrez A, Zapater P, Ricart E, González-Vivó M, Gordillo J, Olivares D, Vera I, Mañosa M, Gisbert JP, Aguas M, Sánchez-Rodríguez E, Bosca-Watts M, Laredo V, Camps B, Marín-Jiménez I, Zabana Y, Martín-Arranz MD, Muñoz R, Navarro M, Sierra E, Madero L, Vela M, Pérez-Calle JL, Sainz E, Calvet X, Arias L, Morales V, Bermejo F, Fernández-Salazar L, Van Domselaar M, De Castro L, Rodríguez C, Muñoz-Villafranca C, Lorente R, Rivero M, Iglesias E, Herreros B, Busquets D, Riera J, Martínez-Montiel MP, Roldón M, Roncero O, Hinojosa E, Sierra M, Barrio J, De Francisco R, Huguet J, Merino O, Carpio D, Ginard D, Muñoz F, Piqueras M, Almela P, Argüelles-Arias F, Alcaín G, Bujanda L, Manceñido N, Lucendo AJ, Varela P, Rodríguez-Lago I, Ramos L, Sempere L, Sesé E, Barreiro-de Acosta M, Domènech E, Francés R. Gutiérrez A, et al. Front Med (Lausanne). 2022 Feb 1;9:823900. doi: 10.3389/fmed.2022.823900. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35178413 Free PMC article.
Random forest-based prediction of stroke outcome.
Fernandez-Lozano C, Hervella P, Mato-Abad V, Rodríguez-Yáñez M, Suárez-Garaboa S, López-Dequidt I, Estany-Gestal A, Sobrino T, Campos F, Castillo J, Rodríguez-Yáñez S, Iglesias-Rey R. Fernandez-Lozano C, et al. Sci Rep. 2021 May 12;11(1):10071. doi: 10.1038/s41598-021-89434-7. Sci Rep. 2021. PMID: 33980906 Free PMC article.
We identified the main variables for machine learning Random Forest (RF), generating a predictive model that can estimate patient mortality/morbidity according to the following groups: (1) IS + ICH, (2) IS, and (3) ICH. ...IS group presented similar results, although varia …
We identified the main variables for machine learning Random Forest (RF), generating a predictive model that can estimate patient mor …
Biallelic loss-of-function LACC1/FAMIN Mutations Presenting as Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis.
Rabionet R, Remesal A, Mensa-Vilaró A, Murías S, Alcobendas R, González-Roca E, Ruiz-Ortiz E, Antón J, Iglesias E, Modesto C, Comas D, Puig A, Drechsel O, Ossowski S, Yagüe J, Merino R, Estivill X, Arostegui JI. Rabionet R, et al. Sci Rep. 2019 Mar 14;9(1):4579. doi: 10.1038/s41598-019-40874-2. Sci Rep. 2019. PMID: 30872671 Free PMC article.
We describe three affected siblings from a Moroccan consanguineous family with an early-onset chronic, symmetric and erosive arthritis previously diagnosed as rheumatoid factor (RF)-negative polyarticular JIA. Autozygosity mapping identified four homozygous regions shared …
We describe three affected siblings from a Moroccan consanguineous family with an early-onset chronic, symmetric and erosive arthritis previ …
The Castilian Spanish version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR).
de Inocencio J, Anton J, Calvo Penades I, Mesa Del Castillo Bermejo P, Alcobendas R, Boteanu AL, Bou R, Iglesias E, González Fernandez MI, López Montesinos B, Santin P, Alcañiz Rodriguez P, Lorente Sanchez MJ, Consolaro A, Bovis F, Ruperto N; Paediatric Rheumatology International Trials Organisation (PRINTO). de Inocencio J, et al. Rheumatol Int. 2018 Apr;38(Suppl 1):91-98. doi: 10.1007/s00296-018-3976-6. Epub 2018 Apr 7. Rheumatol Int. 2018. PMID: 29637328 Free PMC article.
A total of 526 JIA patients (8.6% systemic, 49.4% oligoarticular, 18.2% RF negative polyarthritis, 23.8% other categories) and 78 healthy children, were enrolled in six centres. ...
A total of 526 JIA patients (8.6% systemic, 49.4% oligoarticular, 18.2% RF negative polyarthritis, 23.8% other categories) and 78 hea …
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