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Systemic delivery of mutant huntingtin lowering antisense oligonucleotides to the brain using apolipoprotein A-I nanodisks for Huntington disease.
J Control Release. 2024 Mar;367:27-44. doi: 10.1016/j.jconrel.2024.01.011. Epub 2024 Jan 24.
J Control Release. 2024.
PMID: 38215984
Free article.
Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease.
Caron NS, Banos R, Yanick C, Aly AE, Byrne LM, Smith ED, Xie Y, Smith SEP, Potluri N, Findlay Black H, Casal L, Ko S, Cheung D, Kim H, Seong IS, Wild EJ, Song JJ, Hayden MR, Southwell AL.
Caron NS, et al.
J Neurosci. 2021 Jan 27;41(4):780-796. doi: 10.1523/JNEUROSCI.1865-20.2020. Epub 2020 Dec 11.
J Neurosci. 2021.
PMID: 33310753
Free PMC article.
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Delivery of mutant huntingtin-lowering antisense oligonucleotides to the brain by intranasally administered apolipoprotein A-I nanodisks.
Aly AE, Caron NS, Black HF, Schmidt ME, Anderson C, Ko S, Baddeley HJE, Anderson L, Casal LL, Rahavi RSM, Martin DDO, Hayden MR.
Aly AE, et al. Among authors: casal ll.
J Control Release. 2023 Aug;360:913-927. doi: 10.1016/j.jconrel.2023.07.027. Epub 2023 Jul 27.
J Control Release. 2023.
PMID: 37468110
Free article.
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A Comprehensive Haplotype-Targeting Strategy for Allele-Specific HTT Suppression in Huntington Disease.
Kay C, Collins JA, Caron NS, Agostinho LA, Findlay-Black H, Casal L, Sumathipala D, Dissanayake VHW, Cornejo-Olivas M, Baine F, Krause A, Greenberg JL, Paiva CLA, Squitieri F, Hayden MR.
Kay C, et al.
Am J Hum Genet. 2019 Dec 5;105(6):1112-1125. doi: 10.1016/j.ajhg.2019.10.011. Epub 2019 Nov 7.
Am J Hum Genet. 2019.
PMID: 31708117
Free PMC article.
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Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease.
Wright GEB, Caron NS, Ng B, Casal L, Casazza W, Xu X, Ooi J, Pouladi MA, Mostafavi S, Ross CJD, Hayden MR.
Wright GEB, et al.
Hum Mol Genet. 2020 Sep 29;29(16):2788-2802. doi: 10.1093/hmg/ddaa184.
Hum Mol Genet. 2020.
PMID: 32898862
Free PMC article.
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HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo.
Ehrnhoefer DE, Southwell AL, Sivasubramanian M, Qiu X, Villanueva EB, Xie Y, Waltl S, Anderson L, Fazeli A, Casal L, Felczak B, Tsang M, Hayden MR.
Ehrnhoefer DE, et al.
Hum Mol Genet. 2018 Jan 15;27(2):239-253. doi: 10.1093/hmg/ddx394.
Hum Mol Genet. 2018.
PMID: 29121340
Free PMC article.
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Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli.
Ladha S, Qiu X, Casal L, Caron NS, Ehrnhoefer DE, Hayden MR.
Ladha S, et al.
Cell Death Discov. 2018 Mar 12;4:40. doi: 10.1038/s41420-018-0043-8. eCollection 2018.
Cell Death Discov. 2018.
PMID: 29560279
Free PMC article.
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