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Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.
Haque ME, Thomas KJ, D'Souza C, Callaghan S, Kitada T, Slack RS, Fraser P, Cookson MR, Tandon A, Park DS. Haque ME, et al. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1716-21. doi: 10.1073/pnas.0705363105. Epub 2008 Jan 24. Proc Natl Acad Sci U S A. 2008. PMID: 18218782 Free PMC article.
Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1.
Haque ME, Mount MP, Safarpour F, Abdel-Messih E, Callaghan S, Mazerolle C, Kitada T, Slack RS, Wallace V, Shen J, Anisman H, Park DS. Haque ME, et al. J Biol Chem. 2012 Jun 29;287(27):23162-70. doi: 10.1074/jbc.M112.346437. Epub 2012 Apr 17. J Biol Chem. 2012. PMID: 22511790 Free PMC article.
192 results