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A potential patient stratification biomarker for Parkinson´s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells.
Naaldijk Y, Fernández B, Fasiczka R, Fdez E, Leghay C, Croitoru I, Kwok JB, Boulesnane Y, Vizeneux A, Mutez E, Calvez C, Destée A, Taymans JM, Aragon AV, Yarza AB, Padmanabhan S, Delgado M, Alcalay RN, Chatterton Z, Dzamko N, Halliday G, Ruiz-Martínez J, Chartier-Harlin MC, Hilfiker S. Naaldijk Y, et al. Among authors: destee a. NPJ Parkinsons Dis. 2024 Jan 8;10(1):12. doi: 10.1038/s41531-023-00624-8. NPJ Parkinsons Dis. 2024. PMID: 38191886 Free PMC article.
Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson's disease and pharmacodynamic biomarkers.
Taymans JM, Mutez E, Sibran W, Vandewynckel L, Deldycke C, Bleuse S, Marchand A, Sarchione A, Leghay C, Kreisler A, Simonin C, Koprich J, Baille G, Defebvre L, Dujardin K, Destée A, Chartier-Harlin MC. Taymans JM, et al. Among authors: destee a. NPJ Parkinsons Dis. 2023 Feb 7;9(1):21. doi: 10.1038/s41531-023-00445-9. NPJ Parkinsons Dis. 2023. PMID: 36750568 Free PMC article.
Excessive buccal saliva in patients with Parkinson's disease of the French COPARK cohort.
Rascol O, Negre-Pages L, Damier P, Delval A, Derkinderen P, Destée A, Fabbri M, Meissner WG, Rachdi A, Tison F, Perez-Lloret S; COPARK Study Group. Rascol O, et al. Among authors: destee a. J Neural Transm (Vienna). 2020 Dec;127(12):1607-1617. doi: 10.1007/s00702-020-02249-0. Epub 2020 Sep 2. J Neural Transm (Vienna). 2020. PMID: 32880023
Early cognitive decline after bilateral subthalamic deep brain stimulation in Parkinson's disease patients with GBA mutations.
Mangone G, Bekadar S, Cormier-Dequaire F, Tahiri K, Welaratne A, Czernecki V, Pineau F, Karachi C, Castrioto A, Durif F, Tranchant C, Devos D, Thobois S, Meissner WG, Navarro MS, Cornu P, Lesage S, Brice A, Welter ML, Corvol JC; contributors/investigators. Mangone G, et al. Parkinsonism Relat Disord. 2020 Jul;76:56-62. doi: 10.1016/j.parkreldis.2020.04.002. Epub 2020 Jun 9. Parkinsonism Relat Disord. 2020. PMID: 32866938
Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients.
Fernández B, Lara Ordóñez AJ, Fdez E, Mutez E, Comptdaer T, Leghay C, Kreisler A, Simonin C, Vandewynckel L, Defebvre L, Destée A, Bleuse S, Taymans JM, Chartier-Harlin MC, Hilfiker S. Fernández B, et al. Among authors: destee a. Biochem J. 2019 Oct 15;476(19):2797-2813. doi: 10.1042/BCJ20190315. Biochem J. 2019. PMID: 31527116 Free PMC article.
LRP10 in α-synucleinopathies.
Tesson C, Brefel-Courbon C, Corvol JC, Lesage S, Brice A; French Parkinson's Disease Genetics Study Group. Tesson C, et al. Lancet Neurol. 2018 Dec;17(12):1034. doi: 10.1016/S1474-4422(18)30400-9. Epub 2018 Nov 13. Lancet Neurol. 2018. PMID: 30507386 Free article. No abstract available.
Overexpression of Wild-Type Human Alpha-Synuclein Causes Metabolism Abnormalities in Thy1-aSYN Transgenic Mice.
Cuvelier E, Méquinion M, Leghay C, Sibran W, Stievenard A, Sarchione A, Bonte MA, Vanbesien-Mailliot C, Viltart O, Saitoski K, Caron E, Labarthe A, Comptdaer T, Semaille P, Carrié H, Mutez E, Gressier B, Destée A, Chartier-Harlin MC, Belarbi K. Cuvelier E, et al. Among authors: destee a. Front Mol Neurosci. 2018 Oct 2;11:321. doi: 10.3389/fnmol.2018.00321. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30333721 Free PMC article.
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