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Efficacy, safety, and pharmacokinetics of capsid assembly modulator linvencorvir plus standard of care in chronic hepatitis B patients.
Hou J, Gane E, Balabanska R, Zhang W, Zhang J, Lim TH, Xie Q, Yeh CT, Yang SS, Liang X, Komolmit P, Leerapun A, Xue Z, Chen E, Zhang Y, Xie Q, Chang TT, Hu TH, Lim SG, Chuang WL, Leggett B, Bo Q, Zhou X, Triyatni M, Zhang W, Yuen MF. Hou J, et al. Among authors: bo q. Clin Mol Hepatol. 2024 Apr;30(2):191-205. doi: 10.3350/cmh.2023.0422. Epub 2024 Jan 8. Clin Mol Hepatol. 2024. PMID: 38190830 Free PMC article. Clinical Trial.
Safety, pharmacokinetics, and antiviral activity of RO7049389, a core protein allosteric modulator, in patients with chronic hepatitis B virus infection: a multicentre, randomised, placebo-controlled, phase 1 trial.
Yuen MF, Zhou X, Gane E, Schwabe C, Tanwandee T, Feng S, Jin Y, Triyatni M, Lemenuel-Diot A, Cosson V, Xue Z, Kazma R, Bo Q. Yuen MF, et al. Among authors: bo q. Lancet Gastroenterol Hepatol. 2021 Sep;6(9):723-732. doi: 10.1016/S2468-1253(21)00176-X. Epub 2021 Jul 6. Lancet Gastroenterol Hepatol. 2021. PMID: 34237271 Clinical Trial.
A Five-in-One First-in-Human Study To Assess Safety, Tolerability, and Pharmacokinetics of RO7049389, an Inhibitor of Hepatitis B Virus Capsid Assembly, after Single and Multiple Ascending Doses in Healthy Participants.
Feng S, Gane E, Schwabe C, Zhu M, Triyatni M, Zhou J, Bo Q, Jin Y. Feng S, et al. Among authors: bo q. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01323-20. doi: 10.1128/AAC.01323-20. Print 2020 Oct 20. Antimicrob Agents Chemother. 2020. PMID: 32839221 Free PMC article. Clinical Trial.
How Semiphysiological Population Pharmacokinetic Modeling Incorporating Active Hepatic Uptake Supports Phase II Dose Selection of RO7049389, A Novel Anti-Hepatitis B Virus Drug.
Cosson V, Feng S, Jaminion F, Lemenuel-Diot A, Parrott N, Paehler A, Bo Q, Jin Y. Cosson V, et al. Among authors: bo q. Clin Pharmacol Ther. 2021 Apr;109(4):1081-1091. doi: 10.1002/cpt.2184. Epub 2021 Mar 10. Clin Pharmacol Ther. 2021. PMID: 33523474 Free PMC article. Clinical Trial.
What drives the dynamics of HBV RNA during treatment?
Gonçalves A, Lemenuel-Diot A, Cosson V, Jin Y, Feng S, Bo Q, Guedj J. Gonçalves A, et al. Among authors: bo q. J Viral Hepat. 2021 Feb;28(2):383-392. doi: 10.1111/jvh.13425. Epub 2020 Nov 2. J Viral Hepat. 2021. PMID: 33074571
214 results