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HDAC inhibitors activate lipid peroxidation and ferroptosis in gastric cancer.
Jenke R, Oliinyk D, Zenz T, Körfer J, Schäker-Hübner L, Hansen FK, Lordick F, Meier-Rosar F, Aigner A, Büch T. Jenke R, et al. Among authors: schaker hubner l. Biochem Pharmacol. 2024 May 4;225:116257. doi: 10.1016/j.bcp.2024.116257. Online ahead of print. Biochem Pharmacol. 2024. PMID: 38705532 Free article.
Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia.
Reßing N, Schliehe-Diecks J, Watson PR, Sönnichsen M, Cragin AD, Schöler A, Yang J, Schäker-Hübner L, Borkhardt A, Christianson DW, Bhatia S, Hansen FK. Reßing N, et al. Among authors: schaker hubner l. J Med Chem. 2022 Nov 24;65(22):15457-15472. doi: 10.1021/acs.jmedchem.2c01418. Epub 2022 Nov 9. J Med Chem. 2022. PMID: 36351184 Free PMC article.
Development of the first non-hydroxamate selective HDAC6 degraders.
Keuler T, König B, Bückreiß N, Kraft FB, König P, Schäker-Hübner L, Steinebach C, Bendas G, Gütschow M, Hansen FK. Keuler T, et al. Among authors: schaker hubner l. Chem Commun (Camb). 2022 Oct 4;58(79):11087-11090. doi: 10.1039/d2cc03712b. Chem Commun (Camb). 2022. PMID: 36098075
Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [18F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain.
Clauß O, Schäker-Hübner L, Wenzel B, Toussaint M, Deuther-Conrad W, Gündel D, Teodoro R, Dukić-Stefanović S, Ludwig FA, Kopka K, Brust P, Hansen FK, Scheunemann M. Clauß O, et al. Among authors: schaker hubner l. Pharmaceuticals (Basel). 2022 Mar 8;15(3):324. doi: 10.3390/ph15030324. Pharmaceuticals (Basel). 2022. PMID: 35337122 Free PMC article.
4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads.
Schäker-Hübner L, Warstat R, Ahlert H, Mishra P, Kraft FB, Schliehe-Diecks J, Schöler A, Borkhardt A, Breit B, Bhatia S, Hügle M, Günther S, Hansen FK. Schäker-Hübner L, et al. J Med Chem. 2021 Oct 14;64(19):14620-14646. doi: 10.1021/acs.jmedchem.1c01119. Epub 2021 Sep 28. J Med Chem. 2021. PMID: 34582215