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The evolutionary conserved miR-137/325 tandem mediates obesity-induced hypogonadism and metabolic comorbidities by repressing hypothalamic kisspeptin.
Avendaño MS, Perdices-Lopez C, Guerrero-Ruiz Y, Ruiz-Pino F, Rodriguez-Sanchez AB, Sanchez-Tapia MJ, Sobrino V, Pineda R, Barroso A, Correa-Sáez A, Lara-Chica M, Fernandez-Garcia JC, García-Redondo AB, Hernanz R, Ruiz-Cruz M, Garcia-Galiano D, Pitteloud N, Calzado MA, Briones AM, Vázquez MJ, Tena-Sempere M. Avendaño MS, et al. Among authors: correa saez a. Metabolism. 2024 May 8:155932. doi: 10.1016/j.metabol.2024.155932. Online ahead of print. Metabolism. 2024. PMID: 38729600 Free article.
Targeted protein degradation via intramolecular bivalent glues.
Hsia O, Hinterndorfer M, Cowan AD, Iso K, Ishida T, Sundaramoorthy R, Nakasone MA, Imrichova H, Schätz C, Rukavina A, Husnjak K, Wegner M, Correa-Sáez A, Craigon C, Casement R, Maniaci C, Testa A, Kaulich M, Dikic I, Winter GE, Ciulli A. Hsia O, et al. Among authors: correa saez a. Nature. 2024 Mar;627(8002):204-211. doi: 10.1038/s41586-024-07089-6. Epub 2024 Feb 21. Nature. 2024. PMID: 38383787 Free PMC article.
Localization, traffic and function of Rab34 in adipocyte lipid and endocrine functions.
López-Alcalá J, Gordon A, Trávez A, Tercero-Alcázar C, Correa-Sáez A, González-Rellán MJ, Rangel-Zúñiga OA, Rodríguez A, Membrives A, Frühbeck G, Nogueiras R, Calzado MA, Guzmán-Ruiz R, Malagón MM. López-Alcalá J, et al. Among authors: correa saez a. J Biomed Sci. 2024 Jan 5;31(1):2. doi: 10.1186/s12929-023-00990-8. J Biomed Sci. 2024. PMID: 38183057 Free PMC article.
FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2.
Jiménez-Izquierdo R, Morrugares R, Suanes-Cobos L, Correa-Sáez A, Garrido-Rodríguez M, Cerero-Tejero L, Khan OM, de la Luna S, Sancho R, Calzado MA. Jiménez-Izquierdo R, et al. Among authors: correa saez a. Cell Death Dis. 2023 Mar 18;14(3):202. doi: 10.1038/s41419-023-05724-0. Cell Death Dis. 2023. PMID: 36934104 Free PMC article.
A cannabidiol aminoquinone derivative activates the PP2A/B55α/HIF pathway and shows protective effects in a murine model of traumatic brain injury.
Navarrete C, García-Martín A, Correa-Sáez A, Prados ME, Fernández F, Pineda R, Mazzone M, Álvarez-Benito M, Calzado MA, Muñoz E. Navarrete C, et al. Among authors: correa saez a. J Neuroinflammation. 2022 Jul 9;19(1):177. doi: 10.1186/s12974-022-02540-9. J Neuroinflammation. 2022. PMID: 35810304 Free PMC article.
A novel CDC25A/DYRK2 regulatory switch modulates cell cycle and survival.
Lara-Chica M, Correa-Sáez A, Jiménez-Izquierdo R, Garrido-Rodríguez M, Ponce FJ, Moreno R, Morrison K, Di Vona C, Arató K, Jiménez-Jiménez C, Morrugares R, Schmitz ML, de la Luna S, de la Vega L, Calzado MA. Lara-Chica M, et al. Among authors: correa saez a. Cell Death Differ. 2022 Jan;29(1):105-117. doi: 10.1038/s41418-021-00845-5. Epub 2021 Aug 6. Cell Death Differ. 2022. PMID: 34363019 Free PMC article.
Betulinic Acid Hydroxamate is Neuroprotective and Induces Protein Phosphatase 2A-Dependent HIF-1α Stabilization and Post-transcriptional Dephosphorylation of Prolyl Hydrolase 2.
Prados ME, Correa-Sáez A, Unciti-Broceta JD, Garrido-Rodríguez M, Jimenez-Jimenez C, Mazzone M, Minassi A, Appendino G, Calzado MA, Muñoz E. Prados ME, et al. Among authors: correa saez a. Neurotherapeutics. 2021 Jul;18(3):1849-1861. doi: 10.1007/s13311-021-01089-4. Epub 2021 Aug 2. Neurotherapeutics. 2021. PMID: 34339019 Free PMC article.