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Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation.
Bravo González-Blas C, Matetovici I, Hillen H, Taskiran II, Vandepoel R, Christiaens V, Sansores-García L, Verboven E, Hulselmans G, Poovathingal S, Demeulemeester J, Psatha N, Mauduit D, Halder G, Aerts S. Bravo González-Blas C, et al. Among authors: hillen h. Nat Cell Biol. 2024 Jan;26(1):153-167. doi: 10.1038/s41556-023-01316-4. Epub 2024 Jan 5. Nat Cell Biol. 2024. PMID: 38182825 Free PMC article.
Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice.
Moya IM, Castaldo SA, Van den Mooter L, Soheily S, Sansores-Garcia L, Jacobs J, Mannaerts I, Xie J, Verboven E, Hillen H, Algueró-Nadal A, Karaman R, Van Haele M, Kowalczyk W, De Waegeneer M, Verhulst S, Karras P, van Huffel L, Zender L, Marine JC, Roskams T, Johnson R, Aerts S, van Grunsven LA, Halder G. Moya IM, et al. Among authors: hillen h. Science. 2019 Nov 22;366(6468):1029-1034. doi: 10.1126/science.aaw9886. Science. 2019. PMID: 31754005
Hippo signaling instructs ectopic but not normal organ growth.
Kowalczyk W, Romanelli L, Atkins M, Hillen H, Bravo González-Blas C, Jacobs J, Xie J, Soheily S, Verboven E, Moya IM, Verhulst S, de Waegeneer M, Sansores-Garcia L, van Huffel L, Johnson RL, van Grunsven LA, Aerts S, Halder G. Kowalczyk W, et al. Among authors: hillen h. Science. 2022 Nov 18;378(6621):eabg3679. doi: 10.1126/science.abg3679. Epub 2022 Nov 18. Science. 2022. PMID: 36395225
Regeneration Defects in Yap and Taz Mutant Mouse Livers Are Caused by Bile Duct Disruption and Cholestasis.
Verboven E, Moya IM, Sansores-Garcia L, Xie J, Hillen H, Kowalczyk W, Vella G, Verhulst S, Castaldo SA, Algueró-Nadal A, Romanelli L, Mercader-Celma C, Souza NA, Soheily S, Van Huffel L, Van Brussel T, Lambrechts D, Roskams T, Lemaigre FP, Bergers G, van Grunsven LA, Halder G. Verboven E, et al. Among authors: hillen h. Gastroenterology. 2021 Feb;160(3):847-862. doi: 10.1053/j.gastro.2020.10.035. Epub 2020 Oct 28. Gastroenterology. 2021. PMID: 33127392 Free article.
A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models.
Hillen H, Candi A, Vanderhoydonck B, Kowalczyk W, Sansores-Garcia L, Kesikiadou EC, Van Huffel L, Spiessens L, Nijs M, Soons E, Haeck W, Klaassen H, Smets W, Spieser SA, Marchand A, Chaltin P, Ciesielski F, Debaene F, Chen L, Kamal A, Gwaltney SL, Versele M, Halder GA. Hillen H, et al. Mol Cancer Ther. 2024 Jan 3;23(1):3-13. doi: 10.1158/1535-7163.MCT-22-0681. Mol Cancer Ther. 2024. PMID: 37748190
Structure of the multi-subunit chloroplast RNA polymerase.
do Prado PFV, Ahrens FM, Liebers M, Ditz N, Braun HP, Pfannschmidt T, Hillen HS. do Prado PFV, et al. Among authors: hillen hs. Mol Cell. 2024 Mar 7;84(5):910-925.e5. doi: 10.1016/j.molcel.2024.02.003. Epub 2024 Feb 29. Mol Cell. 2024. PMID: 38428434 Free article.
Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria.
Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P. Poerschke S, et al. Among authors: hillen hs. Mol Cell. 2024 Jan 18;84(2):345-358.e5. doi: 10.1016/j.molcel.2023.12.013. Epub 2024 Jan 9. Mol Cell. 2024. PMID: 38199007 Free PMC article.
148 results