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Substrate stiffness promotes vascular smooth muscle cell calcification by reducing the levels of nuclear actin monomers.
J Mol Cell Cardiol. 2024 Feb;187:65-79. doi: 10.1016/j.yjmcc.2023.12.005. Epub 2024 Jan 5.
J Mol Cell Cardiol. 2024.
PMID: 38181546
Elevated cyclic-AMP represses expression of exchange protein activated by cAMP (EPAC1) by inhibiting YAP-TEAD activity and HDAC-mediated histone deacetylation.
Ebrahimighaei R, McNeill MC, Smith SA, Wray JP, Ford KL, Newby AC, Bond M.
Ebrahimighaei R, et al. Among authors: mcneill mc.
Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1634-1649. doi: 10.1016/j.bbamcr.2019.06.013. Epub 2019 Jun 28.
Biochim Biophys Acta Mol Cell Res. 2019.
PMID: 31255721
Free article.
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Nuclear actin regulates cell proliferation and migration via inhibition of SRF and TEAD.
McNeill MC, Wray J, Sala-Newby GB, Hindmarch CCT, Smith SA, Ebrahimighaei R, Newby AC, Bond M.
McNeill MC, et al.
Biochim Biophys Acta Mol Cell Res. 2020 Jul;1867(7):118691. doi: 10.1016/j.bbamcr.2020.118691. Epub 2020 Feb 28.
Biochim Biophys Acta Mol Cell Res. 2020.
PMID: 32119877
Free PMC article.
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Cyclic-AMP Increases Nuclear Actin Monomer Which Promotes Proteasomal Degradation of RelA/p65 Leading to Anti-Inflammatory Effects.
Hawkins JW, McNeill MC, Ebrahimighaei R, Mellor HH, Newby AC, Bond M.
Hawkins JW, et al. Among authors: mcneill mc.
Cells. 2022 Apr 21;11(9):1414. doi: 10.3390/cells11091414.
Cells. 2022.
PMID: 35563720
Free PMC article.
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Combined role for YAP-TEAD and YAP-RUNX2 signalling in substrate-stiffness regulation of cardiac fibroblast proliferation.
Ebrahimighaei R, Sala-Newby GB, Hudson C, Kimura TE, Hathway T, Hawkins J, McNeill MC, Richardson R, Newby AC, Bond M.
Ebrahimighaei R, et al. Among authors: mcneill mc.
Biochim Biophys Acta Mol Cell Res. 2022 Nov;1869(11):119329. doi: 10.1016/j.bbamcr.2022.119329. Epub 2022 Jul 26.
Biochim Biophys Acta Mol Cell Res. 2022.
PMID: 35905788
Free article.
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Extracellular matrix stiffness controls cardiac fibroblast proliferation via the nuclear factor-Y (NF-Y) transcription factor.
Ebrahimighaei R, Tarassova N, Bond SC, McNeill MC, Hathway T, Vohra H, Newby AC, Bond M.
Ebrahimighaei R, et al. Among authors: mcneill mc.
Biochim Biophys Acta Mol Cell Res. 2024 Feb;1871(2):119640. doi: 10.1016/j.bbamcr.2023.119640. Epub 2023 Nov 22.
Biochim Biophys Acta Mol Cell Res. 2024.
PMID: 37996060
Free article.
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Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking.
Smith SA, Sessions RB, Shoemark DK, Williams C, Ebrahimighaei R, McNeill MC, Crump MP, McKay TR, Harris G, Newby AC, Bond M.
Smith SA, et al. Among authors: mcneill mc.
J Med Chem. 2019 Feb 14;62(3):1291-1305. doi: 10.1021/acs.jmedchem.8b01402. Epub 2019 Jan 31.
J Med Chem. 2019.
PMID: 30640473
Free PMC article.
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