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Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome.
Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2309579121. doi: 10.1073/pnas.2309579121. Epub 2024 Jan 4.
Proc Natl Acad Sci U S A. 2024.
PMID: 38175865
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.
Robinson KS, Toh GA, Rozario P, Chua R, Bauernfried S, Sun Z, Firdaus MJ, Bayat S, Nadkarni R, Poh ZS, Tham KC, Harapas CR, Lim CK, Chu W, Tay CWS, Tan KY, Zhao T, Bonnard C, Sobota R, Connolly JE, Common J, Masters SL, Chen KW, Ho L, Wu B, Hornung V, Zhong FL.
Robinson KS, et al. Among authors: firdaus mj.
Science. 2022 Jul 15;377(6603):328-335. doi: 10.1126/science.abl6324. Epub 2022 Jul 14.
Science. 2022.
PMID: 35857590
Free PMC article.
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Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis.
Robinson KS, Toh GA, Firdaus MJ, Tham KC, Rozario P, Lim CK, Toh YX, Lau ZH, Binder SC, Mayer J, Bonnard C, Schmidt FI, Common JEA, Zhong FL.
Robinson KS, et al. Among authors: firdaus mj.
J Exp Med. 2023 Oct 2;220(10):e20230105. doi: 10.1084/jem.20230105. Epub 2023 Aug 29.
J Exp Med. 2023.
PMID: 37642997
Free PMC article.
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Detrimental Effects of IFN-γ on an Epidermolysis Bullosa Simplex Cell Model and Protection by a Humanized Anti-IFN-γ Monoclonal Antibody.
Badowski C, Tan TS, Aliev T, Trudil D, Larina M, Argentova V, Firdaus MJ, Benny P, Woo VST, Lane EB.
Badowski C, et al. Among authors: firdaus mj.
JID Innov. 2022 Jan 13;2(2):100096. doi: 10.1016/j.xjidi.2022.100096. eCollection 2022 Mar.
JID Innov. 2022.
PMID: 35265936
Free PMC article.
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A cell-based drug discovery assay identifies inhibition of cell stress responses as a new approach to treatment of epidermolysis bullosa simplex.
Tan TS, Common JEA, Lim JSY, Badowski C, Firdaus MJ, Leonardi SS, Lane EB.
Tan TS, et al. Among authors: firdaus mj.
J Cell Sci. 2021 Oct 1;134(19):jcs258409. doi: 10.1242/jcs.258409. Epub 2021 Oct 13.
J Cell Sci. 2021.
PMID: 34643242
Free PMC article.
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