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Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid.
Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2309700120. doi: 10.1073/pnas.2309700120. Epub 2024 Jan 3.
Proc Natl Acad Sci U S A. 2024.
PMID: 38170745
Free PMC article.
Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein.
Ulamec SM, Maya-Martinez R, Byrd EJ, Dewison KM, Xu Y, Willis LF, Sobott F, Heath GR, van Oosten Hawle P, Buchman VL, Radford SE, Brockwell DJ.
Ulamec SM, et al.
Nat Commun. 2022 Aug 25;13(1):4986. doi: 10.1038/s41467-022-32687-1.
Nat Commun. 2022.
PMID: 36008493
Free PMC article.
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Looking Beyond the Core: The Role of Flanking Regions in the Aggregation of Amyloidogenic Peptides and Proteins.
Ulamec SM, Brockwell DJ, Radford SE.
Ulamec SM, et al.
Front Neurosci. 2020 Dec 1;14:611285. doi: 10.3389/fnins.2020.611285. eCollection 2020.
Front Neurosci. 2020.
PMID: 33335475
Free PMC article.
Review.
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Spot the Difference: Function versus Toxicity in Amyloid Fibrils.
Ulamec SM, Radford SE.
Ulamec SM, et al.
Trends Biochem Sci. 2020 Aug;45(8):635-636. doi: 10.1016/j.tibs.2020.04.007. Epub 2020 May 3.
Trends Biochem Sci. 2020.
PMID: 32376150
Free article.
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A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function.
Doherty CPA, Ulamec SM, Maya-Martinez R, Good SC, Makepeace J, Khan GN, van Oosten-Hawle P, Radford SE, Brockwell DJ.
Doherty CPA, et al. Among authors: ulamec sm.
Nat Struct Mol Biol. 2020 Mar;27(3):249-259. doi: 10.1038/s41594-020-0384-x. Epub 2020 Mar 9.
Nat Struct Mol Biol. 2020.
PMID: 32157247
Free PMC article.
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Photoinduced Electron Transfer between Psoralens and DNA: Influence of DNA Sequence and Substitution.
Fröbel S, Levi L, Ulamec SM, Gilch P.
Fröbel S, et al. Among authors: ulamec sm.
Chemphyschem. 2016 May 4;17(9):1377-86. doi: 10.1002/cphc.201500889. Epub 2015 Nov 26.
Chemphyschem. 2016.
PMID: 26607751
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