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Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease.
Fattahi F, Steinbeck JA, Kriks S, Tchieu J, Zimmer B, Kishinevsky S, Zeltner N, Mica Y, El-Nachef W, Zhao H, de Stanchina E, Gershon MD, Grikscheit TC, Chen S, Studer L. Fattahi F, et al. Among authors: chen s. Nature. 2016 Mar 3;531(7592):105-9. doi: 10.1038/nature16951. Epub 2016 Feb 10. Nature. 2016. PMID: 26863197 Free PMC article.
High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.
Zhou T, Tan L, Cederquist GY, Fan Y, Hartley BJ, Mukherjee S, Tomishima M, Brennand KJ, Zhang Q, Schwartz RE, Evans T, Studer L, Chen S. Zhou T, et al. Among authors: chen s. Cell Stem Cell. 2017 Aug 3;21(2):274-283.e5. doi: 10.1016/j.stem.2017.06.017. Epub 2017 Jul 20. Cell Stem Cell. 2017. PMID: 28736217 Free PMC article.
ROCKII inhibition promotes the maturation of human pancreatic beta-like cells.
Ghazizadeh Z, Kao DI, Amin S, Cook B, Rao S, Zhou T, Zhang T, Xiang Z, Kenyon R, Kaymakcalan O, Liu C, Evans T, Chen S. Ghazizadeh Z, et al. Among authors: chen s. Nat Commun. 2017 Aug 21;8(1):298. doi: 10.1038/s41467-017-00129-y. Nat Commun. 2017. PMID: 28824164 Free PMC article.
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival.
Zhou T, Kim TW, Chong CN, Tan L, Amin S, Sadat Badieyan Z, Mukherjee S, Ghazizadeh Z, Zeng H, Guo M, Crespo M, Zhang T, Kenyon R, Robinson CL, Apostolou E, Wang H, Xiang JZ, Evans T, Studer L, Chen S. Zhou T, et al. Among authors: chen s. Nat Commun. 2018 Nov 16;9(1):4815. doi: 10.1038/s41467-018-07201-1. Nat Commun. 2018. PMID: 30446643 Free PMC article.
Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation.
Li QV, Dixon G, Verma N, Rosen BP, Gordillo M, Luo R, Xu C, Wang Q, Soh CL, Yang D, Crespo M, Shukla A, Xiang Q, Dündar F, Zumbo P, Witkin M, Koche R, Betel D, Chen S, Massagué J, Garippa R, Evans T, Beer MA, Huangfu D. Li QV, et al. Among authors: chen s. Nat Genet. 2019 Jun;51(6):999-1010. doi: 10.1038/s41588-019-0408-9. Epub 2019 May 20. Nat Genet. 2019. PMID: 31110351 Free PMC article.
Author Correction: A recellularized human colon model identifies cancer driver genes.
Chen HJ, Wei Z, Sun J, Bhattacharya A, Savage DJ, Serda R, Mackeyev Y, Curley SA, Bu P, Wang L, Chen S, Cohen-Gould L, Huang E, Shen X, Lipkin SM, Copeland NG, Jenkins NA, Shuler ML. Chen HJ, et al. Among authors: chen s. Nat Biotechnol. 2019 Jul;37(7):820. doi: 10.1038/s41587-019-0163-6. Nat Biotechnol. 2019. PMID: 31160724
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