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From transglutaminases (TGs) to arylamine N-acetyltransferases (NATs): Insight into the role of a spatially conserved aromatic amino acid position in the active site of these two families of enzymes.
Xu X, Zhang W, Berthelet J, Liu R, Michail C, Chaffotte AF, Dupret JM, Rodrigues-Lima F. Xu X, et al. Among authors: rodrigues lima f. Biochem Biophys Res Commun. 2020 Apr 30;525(2):308-312. doi: 10.1016/j.bbrc.2020.02.082. Epub 2020 Feb 20. Biochem Biophys Res Commun. 2020. PMID: 32089267
The conserved glycine/alanine residue of the active-site loop containing the putative acetylCoA-binding motif is essential for the overall structural integrity of Mesorhizobium loti arylamine N-acetyltransferase 1.
Atmane N, Dairou J, Flatters D, Martins M, Pluvinage B, Derreumaux P, Dupret JM, Rodrigues-Lima F. Atmane N, et al. Among authors: rodrigues lima f. Biochem Biophys Res Commun. 2007 Sep 14;361(1):256-62. doi: 10.1016/j.bbrc.2007.07.034. Epub 2007 Jul 17. Biochem Biophys Res Commun. 2007. PMID: 17658468
The Benzene Hematotoxic and Reactive Metabolite 1,4-Benzoquinone Impairs the Activity of the Histone Methyltransferase SET Domain Containing 2 (SETD2) and Causes Aberrant Histone H3 Lysine 36 Trimethylation (H3K36me3).
Berthelet J, Michail C, Bui LC, Le Coadou L, Sirri V, Wang L, Dulphy N, Dupret JM, Chomienne C, Guidez F, Rodrigues-Lima F. Berthelet J, et al. Among authors: rodrigues lima f. Mol Pharmacol. 2021 Sep;100(3):283-294. doi: 10.1124/molpharm.121.000303. Epub 2021 Jul 15. Mol Pharmacol. 2021. PMID: 34266924
125 results