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Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults.
Eur J Med Chem. 2024 Apr 15;270:116353. doi: 10.1016/j.ejmech.2024.116353. Epub 2024 Mar 20.
Eur J Med Chem. 2024.
PMID: 38579622
Free article.
Small Molecules for the Treatment of Long-COVID-Related Vascular Damage and Abnormal Blood Clotting: A Patent-Based Appraisal.
Samarelli F, Graziano G, Gambacorta N, Graps EA, Leonetti F, Nicolotti O, Altomare CD.
Samarelli F, et al.
Viruses. 2024 Mar 14;16(3):450. doi: 10.3390/v16030450.
Viruses. 2024.
PMID: 38543815
Free PMC article.
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Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease.
Lee SH, Purgatorio R, Samarelli F, Catto M, Denora N, Morgese MG, Tucci P, Trabace L, Kim HW, Park HS, Kim SE, Lee BC, de Candia M, Altomare CD.
Lee SH, et al. Among authors: samarelli f.
Arch Pharm (Weinheim). 2024 Mar;357(3):e2300491. doi: 10.1002/ardp.202300491. Epub 2023 Dec 29.
Arch Pharm (Weinheim). 2024.
PMID: 38158335
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Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease.
Czarnota-Łydka K, Sudoł-Tałaj S, Kucwaj-Brysz K, Kurczab R, Satała G, de Candia M, Samarelli F, Altomare CD, Carocci A, Barbarossa A, Żesławska E, Głuch-Lutwin M, Mordyl B, Kubacka M, Wilczyńska-Zawal N, Jastrzębska-Więsek M, Partyka A, Khan N, Więcek M, Nitek W, Honkisz-Orzechowska E, Latacz G, Wesołowska A, Carrieri A, Handzlik J.
Czarnota-Łydka K, et al. Among authors: samarelli f.
Eur J Med Chem. 2023 Nov 5;259:115695. doi: 10.1016/j.ejmech.2023.115695. Epub 2023 Jul 30.
Eur J Med Chem. 2023.
PMID: 37567058
Free article.
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Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases.
Purgatorio R, Gambacorta N, Samarelli F, Lopopolo G, de Candia M, Catto M, Nicolotti O, Altomare CD.
Purgatorio R, et al. Among authors: samarelli f.
Molecules. 2022 Jul 2;27(13):4269. doi: 10.3390/molecules27134269.
Molecules. 2022.
PMID: 35807514
Free PMC article.
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