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PI3KCIIα-Dependent Autophagy Program Protects From Endothelial Dysfunction and Atherosclerosis in Response to Low Shear Stress in Mice.
Nasr M, Fay A, Lupieri A, Malet N, Darmon A, Zahreddine R, Swiader A, Wahart A, Viaud J, Nègre-Salvayre A, Hirsch E, Monteyne D, Perez-Morgà D, Dupont N, Codogno P, Ramel D, Morel E, Laffargue M, Gayral S. Nasr M, et al. Among authors: hirsch e. Arterioscler Thromb Vasc Biol. 2024 Mar;44(3):620-634. doi: 10.1161/ATVBAHA.123.319978. Epub 2023 Dec 28. Arterioscler Thromb Vasc Biol. 2024. PMID: 38152888 Free article.
Resistance to thromboembolism in PI3Kgamma-deficient mice.
Hirsch E, Bosco O, Tropel P, Laffargue M, Calvez R, Altruda F, Wymann M, Montrucchio G. Hirsch E, et al. FASEB J. 2001 Sep;15(11):2019-21. doi: 10.1096/fj.00-0810fje. Epub 2001 Jul 9. FASEB J. 2001. PMID: 11511514
Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes.
Fougerat A, Gayral S, Gourdy P, Schambourg A, Rückle T, Schwarz MK, Rommel C, Hirsch E, Arnal JF, Salles JP, Perret B, Breton-Douillon M, Wymann MP, Laffargue M. Fougerat A, et al. Among authors: hirsch e. Circulation. 2008 Mar 11;117(10):1310-7. doi: 10.1161/CIRCULATIONAHA.107.720466. Epub 2008 Feb 11. Circulation. 2008. PMID: 18268153
PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.
Franco I, Gulluni F, Campa CC, Costa C, Margaria JP, Ciraolo E, Martini M, Monteyne D, De Luca E, Germena G, Posor Y, Maffucci T, Marengo S, Haucke V, Falasca M, Perez-Morga D, Boletta A, Merlo GR, Hirsch E. Franco I, et al. Among authors: hirsch e. Dev Cell. 2014 Mar 31;28(6):647-58. doi: 10.1016/j.devcel.2014.01.022. Dev Cell. 2014. PMID: 24697898 Free PMC article.
Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.
Smirnova NF, Gayral S, Pedros C, Loirand G, Vaillant N, Malet N, Kassem S, Calise D, Goudounèche D, Wymann MP, Hirsch E, Gadeau AP, Martinez LO, Saoudi A, Laffargue M. Smirnova NF, et al. Among authors: hirsch e. J Exp Med. 2014 Aug 25;211(9):1779-92. doi: 10.1084/jem.20131276. Epub 2014 Jul 29. J Exp Med. 2014. PMID: 25073791 Free PMC article.
Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation.
Franco I, Margaria JP, De Santis MC, Ranghino A, Monteyne D, Chiaravalli M, Pema M, Campa CC, Ratto E, Gulluni F, Perez-Morga D, Somlo S, Merlo GR, Boletta A, Hirsch E. Franco I, et al. Among authors: hirsch e. J Am Soc Nephrol. 2016 Apr;27(4):1135-44. doi: 10.1681/ASN.2014100967. Epub 2015 Aug 13. J Am Soc Nephrol. 2016. PMID: 26271513 Free PMC article.
PI3K and Calcium Signaling in Cardiovascular Disease.
Ghigo A, Laffargue M, Li M, Hirsch E. Ghigo A, et al. Among authors: hirsch e. Circ Res. 2017 Jul 21;121(3):282-292. doi: 10.1161/CIRCRESAHA.117.310183. Circ Res. 2017. PMID: 28729453 Review.
1,545 results