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Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles.
Kakuda K, Ikenaka K, Kuma A, Doi J, Aguirre C, Wang N, Ajiki T, Choong CJ, Kimura Y, Badawy SMM, Shima T, Nakamura S, Baba K, Nagano S, Nagai Y, Yoshimori T, Mochizuki H. Kakuda K, et al. Among authors: ikenaka k. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2312306120. doi: 10.1073/pnas.2312306120. Epub 2023 Dec 26. Proc Natl Acad Sci U S A. 2024. PMID: 38147546 Free PMC article.
Suppression of autophagic activity by Rubicon is a signature of aging.
Nakamura S, Oba M, Suzuki M, Takahashi A, Yamamuro T, Fujiwara M, Ikenaka K, Minami S, Tabata N, Yamamoto K, Kubo S, Tokumura A, Akamatsu K, Miyazaki Y, Kawabata T, Hamasaki M, Fukui K, Sango K, Watanabe Y, Takabatake Y, Kitajima TS, Okada Y, Mochizuki H, Isaka Y, Antebi A, Yoshimori T. Nakamura S, et al. Among authors: ikenaka k. Nat Commun. 2019 Feb 19;10(1):847. doi: 10.1038/s41467-019-08729-6. Nat Commun. 2019. PMID: 30783089 Free PMC article.
Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.
Hayakawa H, Nakatani R, Ikenaka K, Aguirre C, Choong CJ, Tsuda H, Nagano S, Koike M, Ikeuchi T, Hasegawa M, Papa SM, Nagai Y, Mochizuki H, Baba K. Hayakawa H, et al. Among authors: ikenaka k. Mov Disord. 2020 Feb;35(2):256-267. doi: 10.1002/mds.27887. Epub 2019 Oct 23. Mov Disord. 2020. PMID: 31643109 Free PMC article.
340 results