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The BRCA2 R2645G variant increases DNA binding and induces hyper-recombination.
Nucleic Acids Res. 2023 Dec 24:gkad1222. doi: 10.1093/nar/gkad1222. Online ahead of print.
Nucleic Acids Res. 2023.
PMID: 38142462
Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant.
Mishra AP, Hartford S, Chittela RK, Sahu S, Kharat SS, Alvaro-Aranda L, Contreras-Perez A, Sullivan T, Martin BK, Albaugh M, Southon E, Burkett S, Karim B, Carreira A, Tessarollo L, Sharan SK.
Mishra AP, et al. Among authors: alvaro aranda l.
Cell Death Dis. 2023 Nov 18;14(11):753. doi: 10.1038/s41419-023-06289-8.
Cell Death Dis. 2023.
PMID: 37980415
Free PMC article.
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Replication gap suppression depends on the double-strand DNA binding activity of BRCA2.
Vugic D, Dumoulin I, Martin C, Minello A, Alvaro-Aranda L, Gomez-Escudero J, Chaaban R, Lebdy R, von Nicolai C, Boucherit V, Ribeyre C, Constantinou A, Carreira A.
Vugic D, et al. Among authors: alvaro aranda l.
Nat Commun. 2023 Jan 27;14(1):446. doi: 10.1038/s41467-023-36149-0.
Nat Commun. 2023.
PMID: 36707518
Free PMC article.
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