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Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry.
Proc Natl Acad Sci U S A. 2024 Jun 11;121(24):e2316892121. doi: 10.1073/pnas.2316892121. Epub 2024 Jun 4.
Proc Natl Acad Sci U S A. 2024.
PMID: 38833472
Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes.
Ramsey JR, Shelton PMM, Heiss TK, Olinares PDB, Vostal LE, Soileau H, Grasso M, Casebeer SW, Adaniya S, Miller M, Sun S, Huggins DJ, Myers RW, Chait BT, Vinogradova EV, Kapoor TM.
Ramsey JR, et al. Among authors: vostal le.
J Am Chem Soc. 2024 Jan 10;146(1):62-67. doi: 10.1021/jacs.3c10581. Epub 2023 Dec 22.
J Am Chem Soc. 2024.
PMID: 38134034
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Fine-tuning chemical genetics to identify physiologic drug targets.
Vostal LE, Kapoor TM.
Vostal LE, et al.
Cell Chem Biol. 2023 Nov 16;30(11):1331-1333. doi: 10.1016/j.chembiol.2023.10.017.
Cell Chem Biol. 2023.
PMID: 37977127
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Differential effects of disulfide bond formation in TEM-1 versus CTX-M-9 β-lactamase.
Villanueva M, Vostal LE, Cohen DN, Biesbrock D, Kuwaye EP, Driver SG, Hart KM.
Villanueva M, et al. Among authors: vostal le.
Protein Sci. 2024 Jan;33(1):e4816. doi: 10.1002/pro.4816.
Protein Sci. 2024.
PMID: 37897253
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Allosteric activation of VCP, a AAA unfoldase, by small molecule mimicry.
Jones NH, Liu Q, Urnavicius L, Dahan NE, Vostal LE, Kapoor TM.
Jones NH, et al. Among authors: vostal le.
bioRxiv [Preprint]. 2023 Oct 2:2023.10.02.560478. doi: 10.1101/2023.10.02.560478.
bioRxiv. 2023.
PMID: 37873168
Free PMC article.
Preprint.
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Using a function-first 'scout fragment'-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes.
Ramsey JR, Shelton PMM, Heiss TK, Olinares PDB, Vostal LE, Soileau H, Grasso M, Warrington S, Adaniya S, Miller M, Sun S, Huggins DJ, Myers RW, Chait BT, Vinogradova EV, Kapoor TM.
Ramsey JR, et al. Among authors: vostal le.
bioRxiv [Preprint]. 2023 Sep 26:2023.09.25.559391. doi: 10.1101/2023.09.25.559391.
bioRxiv. 2023.
PMID: 37808863
Free PMC article.
Updated.
Preprint.
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Caspase-1 interdomain linker cleavage is required for pyroptosis.
Ball DP, Taabazuing CY, Griswold AR, Orth EL, Rao SD, Kotliar IB, Vostal LE, Johnson DC, Bachovchin DA.
Ball DP, et al. Among authors: vostal le.
Life Sci Alliance. 2020 Feb 12;3(3):e202000664. doi: 10.26508/lsa.202000664. Print 2020 Mar.
Life Sci Alliance. 2020.
PMID: 32051255
Free PMC article.
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