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Cationic amphiphilic drugs induce accumulation of cytolytic lysoglycerophospholipids in the lysosomes of cancer cells and block their recycling into common membrane glycerophospholipids.
Nielsen IØ, Clemmensen KKB, Fogde DL, Dietrich TN, Giacobini JD, Bilgin M, Jäättelä M, Maeda K. Nielsen IØ, et al. Among authors: giacobini jd. Mol Biol Cell. 2024 Mar 1;35(3):ar25. doi: 10.1091/mbc.E23-06-0263. Epub 2023 Dec 20. Mol Biol Cell. 2024. PMID: 38117591 Free PMC article.