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Cationic amphiphilic drugs induce accumulation of cytolytic lysoglycerophospholipids in the lysosomes of cancer cells and block their recycling into common membrane glycerophospholipids.
Nielsen IØ, Clemmensen KKB, Fogde DL, Dietrich TN, Giacobini JD, Bilgin M, Jäättelä M, Maeda K. Nielsen IØ, et al. Among authors: dietrich tn. Mol Biol Cell. 2024 Mar 1;35(3):ar25. doi: 10.1091/mbc.E23-06-0263. Epub 2023 Dec 20. Mol Biol Cell. 2024. PMID: 38117591 Free PMC article.
Identification of lysosome-targeting drugs with anti-inflammatory activity as potential invasion inhibitors of treatment resistant HER2 positive cancers.
Hansen MB, Postol M, Tvingsholm S, Nielsen IØ, Dietrich TN, Puustinen P, Maeda K, Dinant C, Strauss R, Egan D, Jäättelä M, Kallunki T. Hansen MB, et al. Among authors: dietrich tn. Cell Oncol (Dordr). 2021 Aug;44(4):805-820. doi: 10.1007/s13402-021-00603-2. Epub 2021 May 3. Cell Oncol (Dordr). 2021. PMID: 33939112 Free PMC article.
Annexin A7 mediates lysosome repair independently of ESCRT-III.
Ebstrup ML, Sønder SL, Fogde DL, Heitmann ASB, Dietrich TN, Dias C, Jäättelä M, Maeda K, Nylandsted J. Ebstrup ML, et al. Among authors: dietrich tn. Front Cell Dev Biol. 2024 Jan 23;11:1211498. doi: 10.3389/fcell.2023.1211498. eCollection 2023. Front Cell Dev Biol. 2024. PMID: 38348092 Free PMC article.