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Discovery of harmiprims, harmine-primaquine hybrids, as potent and selective anticancer and antimalarial compounds.
Pavić K, Poje G, Pessanha de Carvalho L, Tandarić T, Marinović M, Fontinha D, Held J, Prudêncio M, Piantanida I, Vianello R, Krošl Knežević I, Perković I, Rajić Z. Pavić K, et al. Among authors: pessanha de carvalho l. Bioorg Med Chem. 2024 May 1;105:117734. doi: 10.1016/j.bmc.2024.117734. Epub 2024 Apr 23. Bioorg Med Chem. 2024. PMID: 38677112
Reverse N-Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR).
Abdullaziz MA, Takada S, Illarionov B, Pessanha de Carvalho L, Sakamoto Y, Höfmann S, Knak T, Kiffe-Delf AL, Mazzone F, Pfeffer K, Kalscheuer R, Bacher A, Held J, Fischer M, Tanaka N, Kurz T. Abdullaziz MA, et al. Among authors: pessanha de carvalho l. ACS Infect Dis. 2024 May 10;10(5):1739-1752. doi: 10.1021/acsinfecdis.4c00100. Epub 2024 Apr 22. ACS Infect Dis. 2024. PMID: 38647213
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application.
Hofer W, Deschner F, Jézéquel G, Pessanha de Carvalho L, Abdel-Wadood N, Pätzold L, Bernecker S, Morgenstern B, Kany AM, Große M, Stadler M, Bischoff M, Hirsch AKH, Held J, Herrmann J, Müller R. Hofer W, et al. Among authors: pessanha de carvalho l. Angew Chem Int Ed Engl. 2024 May 6;63(19):e202319765. doi: 10.1002/anie.202319765. Epub 2024 Apr 3. Angew Chem Int Ed Engl. 2024. PMID: 38502093
The problem of antimalarial resistance and its implications for drug discovery.
Schäfer TM, Pessanha de Carvalho L, Inoue J, Kreidenweiss A, Held J. Schäfer TM, et al. Among authors: pessanha de carvalho l. Expert Opin Drug Discov. 2024 Feb;19(2):209-224. doi: 10.1080/17460441.2023.2284820. Epub 2024 Feb 1. Expert Opin Drug Discov. 2024. PMID: 38108082 Review.
Efficacy and safety of ivermectin for the treatment of Plasmodium falciparum infections in asymptomatic male and female Gabonese adults - a pilot randomized, double-blind, placebo-controlled single-centre phase Ib/IIa clinical trial.
Ekoka Mbassi D, Mombo-Ngoma G, Held J, Okwu DG, Ndzebe-Ndoumba W, Kalkman LC, Ekoka Mbassi FA, Pessanha de Carvalho L, Inoue J, Akinosho MA, Dimessa Mbadinga LB, Yovo EK, Mordmüller B, Kremsner PG, Adegnika AA, Ramharter M, Zoleko-Manego R. Ekoka Mbassi D, et al. Among authors: pessanha de carvalho l. EBioMedicine. 2023 Nov;97:104814. doi: 10.1016/j.ebiom.2023.104814. Epub 2023 Oct 13. EBioMedicine. 2023. PMID: 37839134 Free PMC article. Clinical Trial.
Further investigation of harmicines as novel antiplasmodial agents: Synthesis, structure-activity relationship and insight into the mechanism of action.
Marinović M, Poje G, Perković I, Fontinha D, Prudêncio M, Held J, Pessanha de Carvalho L, Tandarić T, Vianello R, Rajić Z. Marinović M, et al. Among authors: pessanha de carvalho l. Eur J Med Chem. 2021 Nov 15;224:113687. doi: 10.1016/j.ejmech.2021.113687. Epub 2021 Jul 5. Eur J Med Chem. 2021. PMID: 34274829
3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum.
Knaab TC, Held J, Burckhardt BB, Rubiano K, Okombo J, Yeo T, Mok S, Uhlemann AC, Lungerich B, Fischli C, Pessanha de Carvalho L, Mordmüller B, Wittlin S, Fidock DA, Kurz T. Knaab TC, et al. Among authors: pessanha de carvalho l. J Med Chem. 2021 Mar 25;64(6):3035-3047. doi: 10.1021/acs.jmedchem.0c01744. Epub 2021 Mar 5. J Med Chem. 2021. PMID: 33666415 Free PMC article.
Novel Harmicines with Improved Potency against Plasmodium.
Marinović M, Perković I, Fontinha D, Prudêncio M, Held J, Pessanha de Carvalho L, Tandarić T, Vianello R, Zorc B, Rajić Z. Marinović M, et al. Among authors: pessanha de carvalho l. Molecules. 2020 Sep 23;25(19):4376. doi: 10.3390/molecules25194376. Molecules. 2020. PMID: 32977642 Free PMC article.
13 results