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Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site.
Liu Z, Li Y, Chen H, Lai HT, Wang P, Wu SY, Wold EA, Leonard PG, Joseph S, Hu H, Chiang CM, Brasier AR, Tian B, Zhou J. Liu Z, et al. Among authors: hu h. J Med Chem. 2022 Feb 10;65(3):2388-2408. doi: 10.1021/acs.jmedchem.1c01851. Epub 2022 Jan 4. J Med Chem. 2022. PMID: 34982556 Free PMC article.
Inhibition of BET Family Proteins Suppresses African Swine Fever Virus Infection.
Zhao Y, Niu Q, Yang S, Yang J, Zhang Z, Geng S, Fan J, Liu Z, Guan G, Liu Z, Zhou J, Hu H, Luo J, Yin H. Zhao Y, et al. Among authors: hu h. Microbiol Spectr. 2022 Aug 31;10(4):e0241921. doi: 10.1128/spectrum.02419-21. Epub 2022 Jun 27. Microbiol Spectr. 2022. PMID: 35758684 Free PMC article.
Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models.
Hajnik RL, Plante JA, Liang Y, Alameh MG, Tang J, Bonam SR, Zhong C, Adam A, Scharton D, Rafael GH, Liu Y, Hazell NC, Sun J, Soong L, Shi PY, Wang T, Walker DH, Sun J, Weissman D, Weaver SC, Plante KS, Hu H. Hajnik RL, et al. Among authors: hu h. Sci Transl Med. 2022 Sep 14;14(662):eabq1945. doi: 10.1126/scitranslmed.abq1945. Epub 2022 Sep 14. Sci Transl Med. 2022. PMID: 36103514 Free PMC article.
Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants.
Ye Z, Bonam SR, McKay LGA, Plante JA, Walker J, Zhao Y, Huang C, Chen J, Xu C, Li Y, Liu L, Harmon J, Gao S, Song D, Zhang Z, Plante KS, Griffiths A, Chen J, Hu H, Xu Q. Ye Z, et al. Among authors: hu h. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2311752120. doi: 10.1073/pnas.2311752120. Epub 2023 Dec 22. Proc Natl Acad Sci U S A. 2023. PMID: 38134199 Free PMC article.
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