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Impact of Pregnancy on the Pharmacokinetics and Metabolism of Nicotinamide in Humans.
Clin Pharmacol Ther. 2024 Mar;115(3):556-564. doi: 10.1002/cpt.3146. Epub 2024 Jan 11.
Clin Pharmacol Ther. 2024.
PMID: 38093631
Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and midazolam.
Fashe MM, Miner TA, Fallon JK, Schauer AP, Sykes C, Smith PC, Lee CR.
Fashe MM, et al.
Front Pharmacol. 2023 Jul 5;14:1218703. doi: 10.3389/fphar.2023.1218703. eCollection 2023.
Front Pharmacol. 2023.
PMID: 37475714
Free PMC article.
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Impact of pregnancy related hormones on drug metabolizing enzyme and transport protein concentrations in human hepatocytes.
Fashe MM, Fallon JK, Miner TA, Tiley JB, Smith PC, Lee CR.
Fashe MM, et al.
Front Pharmacol. 2022 Sep 21;13:1004010. doi: 10.3389/fphar.2022.1004010. eCollection 2022.
Front Pharmacol. 2022.
PMID: 36210832
Free PMC article.
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The Impact of Pregnancy on Antihypertensive Drug Metabolism and Pharmacokinetics: Current Status and Future Directions.
Mulrenin IR, Garcia JE, Fashe MM, Loop MS, Daubert MA, Urrutia RP, Lee CR.
Mulrenin IR, et al. Among authors: fashe mm.
Expert Opin Drug Metab Toxicol. 2021 Nov;17(11):1261-1279. doi: 10.1080/17425255.2021.2002845.
Expert Opin Drug Metab Toxicol. 2021.
PMID: 34739303
Free PMC article.
Review.
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Species-Specific Differences in the in Vitro Metabolism of Lasiocarpine.
Fashe MM, Juvonen RO, Petsalo A, Räsänen J, Pasanen M.
Fashe MM, et al.
Chem Res Toxicol. 2015 Oct 19;28(10):2034-44. doi: 10.1021/acs.chemrestox.5b00253. Epub 2015 Oct 2.
Chem Res Toxicol. 2015.
PMID: 26395423
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In silico prediction of the site of oxidation by cytochrome P450 3A4 that leads to the formation of the toxic metabolites of pyrrolizidine alkaloids.
Fashe MM, Juvonen RO, Petsalo A, Vepsäläinen J, Pasanen M, Rahnasto-Rilla M.
Fashe MM, et al.
Chem Res Toxicol. 2015 Apr 20;28(4):702-10. doi: 10.1021/tx500478q. Epub 2015 Feb 17.
Chem Res Toxicol. 2015.
PMID: 25651456
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Identification of a new reactive metabolite of pyrrolizidine alkaloid retrorsine: (3H-pyrrolizin-7-yl)methanol.
Fashe MM, Juvonen RO, Petsalo A, Rahnasto-Rilla M, Auriola S, Soininen P, Vepsäläinen J, Pasanen M.
Fashe MM, et al.
Chem Res Toxicol. 2014 Nov 17;27(11):1950-7. doi: 10.1021/tx5002964. Epub 2014 Oct 21.
Chem Res Toxicol. 2014.
PMID: 25295702
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