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Secondary 3-Chloropiperidines: Powerful Alkylating Agents.
Georg M, Laping LA, Billo V, Gatto B, Friedhoff P, Göttlich R. Georg M, et al. Among authors: friedhoff p. ChemistryOpen. 2023 Dec 13:e202300181. doi: 10.1002/open.202300181. Online ahead of print. ChemistryOpen. 2023. PMID: 38088585 Free article.
Reactive Acrylamide-Modified DNA Traps for Accurate Cross-Linking with Cysteine Residues in DNA-Protein Complexes Using Mismatch Repair Protein MutS as a Model.
Monakhova MV, Kubareva EA, Kolesnikov KK, Anashkin VA, Kosaretskiy EM, Zvereva MI, Romanova EA, Friedhoff P, Oretskaya TS, Zatsepin TS. Monakhova MV, et al. Among authors: friedhoff p. Molecules. 2022 Apr 10;27(8):2438. doi: 10.3390/molecules27082438. Molecules. 2022. PMID: 35458636 Free PMC article.
The selection process of licensing a DNA mismatch for repair.
Fernandez-Leiro R, Bhairosing-Kok D, Kunetsky V, Laffeber C, Winterwerp HH, Groothuizen F, Fish A, Lebbink JHG, Friedhoff P, Sixma TK, Lamers MH. Fernandez-Leiro R, et al. Among authors: friedhoff p. Nat Struct Mol Biol. 2021 Apr;28(4):373-381. doi: 10.1038/s41594-021-00577-7. Epub 2021 Apr 5. Nat Struct Mol Biol. 2021. PMID: 33820992
The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair.
Mardenborough YSN, Nitsenko K, Laffeber C, Duboc C, Sahin E, Quessada-Vial A, Winterwerp HHK, Sixma TK, Kanaar R, Friedhoff P, Strick TR, Lebbink JHG. Mardenborough YSN, et al. Among authors: friedhoff p. Nucleic Acids Res. 2019 Dec 16;47(22):11667-11680. doi: 10.1093/nar/gkz834. Nucleic Acids Res. 2019. PMID: 31598722 Free PMC article.
69 results