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A naturally occurring G11S mutation in the 3C-like protease from the SARS-CoV-2 virus dramatically weakens the dimer interface.
Protein Sci. 2024 Jan;33(1):e4857. doi: 10.1002/pro.4857.
Protein Sci. 2024.
PMID: 38058248
Free PMC article.
A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype.
Lemay-St-Denis C, Alejaldre L, Jemouai Z, Lafontaine K, St-Aubin M, Hitache K, Valikhani D, Weerasinghe NW, Létourneau M, Thibodeaux CJ, Doucet N, Baron C, Copp JN, Pelletier JN.
Lemay-St-Denis C, et al. Among authors: weerasinghe nw.
Philos Trans R Soc Lond B Biol Sci. 2023 Feb 27;378(1871):20220040. doi: 10.1098/rstb.2022.0040. Epub 2023 Jan 11.
Philos Trans R Soc Lond B Biol Sci. 2023.
PMID: 36633286
Free PMC article.
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Partially Modified Peptide Intermediates in Lanthipeptide Biosynthesis Alter the Structure and Dynamics of a Lanthipeptide Synthetase.
Habibi Y, Weerasinghe NW, Uggowitzer KA, Thibodeaux CJ.
Habibi Y, et al. Among authors: weerasinghe nw.
J Am Chem Soc. 2022 Jun 15;144(23):10230-10240. doi: 10.1021/jacs.2c00727. Epub 2022 Jun 1.
J Am Chem Soc. 2022.
PMID: 35647706
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Exploring the Conformational Landscape of a Lanthipeptide Synthetase Using Native Mass Spectrometry.
Weerasinghe NW, Habibi Y, Uggowitzer KA, Thibodeaux CJ.
Weerasinghe NW, et al.
Biochemistry. 2021 May 18;60(19):1506-1519. doi: 10.1021/acs.biochem.1c00085. Epub 2021 Apr 22.
Biochemistry. 2021.
PMID: 33887902
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