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Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues.
Crusco A, Bordoni C, Chakroborty A, Whatley KCL, Whiteland H, Westwell AD, Hoffmann KF. Crusco A, et al. Among authors: hoffmann kf. Eur J Med Chem. 2018 May 25;152:87-100. doi: 10.1016/j.ejmech.2018.04.032. Epub 2018 Apr 17. Eur J Med Chem. 2018. PMID: 29698860 Free article.
Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation.
Padalino G, El-Sakkary N, Liu LJ, Liu C, Harte DSG, Barnes RE, Sayers E, Forde-Thomas J, Whiteland H, Bassetto M, Ferla S, Johnson G, Jones AT, Caffrey CR, Chalmers I, Brancale A, Hoffmann KF. Padalino G, et al. Among authors: hoffmann kf. Eur J Med Chem. 2021 Dec 15;226:113823. doi: 10.1016/j.ejmech.2021.113823. Epub 2021 Sep 10. Eur J Med Chem. 2021. PMID: 34536671 Free PMC article.
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes.
Padalino G, Celatka CA, Rienhoff HY Jr, Kalin JH, Cole PA, Lassalle D, Forde-Thomas J, Chalmers IW, Brancale A, Grunau C, Hoffmann KF. Padalino G, et al. Among authors: hoffmann kf. Wellcome Open Res. 2023 Mar 30;8:146. doi: 10.12688/wellcomeopenres.18826.1. eCollection 2023. Wellcome Open Res. 2023. PMID: 37520936 Free PMC article.
Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni.
Partridge FA, Bataille CJR, Forman R, Marriott AE, Forde-Thomas J, Häberli C, Dinsdale RL, O'Sullivan JDB, Willis NJ, Wynne GM, Whiteland H, Archer J, Steven A, Keiser J, Turner JD, Hoffmann KF, Taylor MJ, Else KJ, Russell AJ, Sattelle DB. Partridge FA, et al. Among authors: hoffmann kf. ACS Infect Dis. 2021 May 14;7(5):1260-1274. doi: 10.1021/acsinfecdis.1c00025. Epub 2021 Apr 2. ACS Infect Dis. 2021. PMID: 33797218 Free PMC article.
An Abies procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni.
Whiteland HL, Chakroborty A, Forde-Thomas JE, Crusco A, Cookson A, Hollinshead J, Fenn CA, Bartholomew B, Holdsworth PA, Fisher M, Nash RJ, Hoffmann KF. Whiteland HL, et al. Among authors: hoffmann kf. Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):465-474. doi: 10.1016/j.ijpddr.2018.10.009. Epub 2018 Oct 26. Int J Parasitol Drugs Drug Resist. 2018. PMID: 30399512 Free PMC article.
253 results