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Small Molecule Ligands of the BET-like Bromodomain, SmBRD3, Affect Schistosoma mansoni Survival, Oviposition, and Development.
Schiedel M, McArdle DJB, Padalino G, Chan AKN, Forde-Thomas J, McDonough M, Whiteland H, Beckmann M, Cookson R, Hoffmann KF, Conway SJ. Schiedel M, et al. Among authors: forde thomas j. J Med Chem. 2023 Dec 14;66(23):15801-15822. doi: 10.1021/acs.jmedchem.3c01321. Epub 2023 Dec 4. J Med Chem. 2023. PMID: 38048437 Free PMC article.
Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation.
Padalino G, El-Sakkary N, Liu LJ, Liu C, Harte DSG, Barnes RE, Sayers E, Forde-Thomas J, Whiteland H, Bassetto M, Ferla S, Johnson G, Jones AT, Caffrey CR, Chalmers I, Brancale A, Hoffmann KF. Padalino G, et al. Among authors: forde thomas j. Eur J Med Chem. 2021 Dec 15;226:113823. doi: 10.1016/j.ejmech.2021.113823. Epub 2021 Sep 10. Eur J Med Chem. 2021. PMID: 34536671 Free PMC article.
Using ChEMBL to Complement Schistosome Drug Discovery.
Padalino G, Coghlan A, Pagliuca G, Forde-Thomas JE, Berriman M, Hoffmann KF. Padalino G, et al. Among authors: forde thomas je. Pharmaceutics. 2023 Apr 28;15(5):1359. doi: 10.3390/pharmaceutics15051359. Pharmaceutics. 2023. PMID: 37242601 Free PMC article.
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes.
Padalino G, Celatka CA, Rienhoff HY Jr, Kalin JH, Cole PA, Lassalle D, Forde-Thomas J, Chalmers IW, Brancale A, Grunau C, Hoffmann KF. Padalino G, et al. Among authors: forde thomas j. Wellcome Open Res. 2023 Mar 30;8:146. doi: 10.12688/wellcomeopenres.18826.1. eCollection 2023. Wellcome Open Res. 2023. PMID: 37520936 Free PMC article.
Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni.
Partridge FA, Bataille CJR, Forman R, Marriott AE, Forde-Thomas J, Häberli C, Dinsdale RL, O'Sullivan JDB, Willis NJ, Wynne GM, Whiteland H, Archer J, Steven A, Keiser J, Turner JD, Hoffmann KF, Taylor MJ, Else KJ, Russell AJ, Sattelle DB. Partridge FA, et al. ACS Infect Dis. 2021 May 14;7(5):1260-1274. doi: 10.1021/acsinfecdis.1c00025. Epub 2021 Apr 2. ACS Infect Dis. 2021. PMID: 33797218 Free PMC article.
An Abies procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni.
Whiteland HL, Chakroborty A, Forde-Thomas JE, Crusco A, Cookson A, Hollinshead J, Fenn CA, Bartholomew B, Holdsworth PA, Fisher M, Nash RJ, Hoffmann KF. Whiteland HL, et al. Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):465-474. doi: 10.1016/j.ijpddr.2018.10.009. Epub 2018 Oct 26. Int J Parasitol Drugs Drug Resist. 2018. PMID: 30399512 Free PMC article.
Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal.
Whiteland H, Crusco A, Bloemberg LW, Tibble-Howlings J, Forde-Thomas J, Coghlan A, Murphy PJ, Hoffmann KF. Whiteland H, et al. PLoS Negl Trop Dis. 2020 Oct 19;14(10):e0008630. doi: 10.1371/journal.pntd.0008630. eCollection 2020 Oct. PLoS Negl Trop Dis. 2020. PMID: 33075069 Free PMC article.
Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae.
Gasan TA, Kuipers ME, Roberts GH, Padalino G, Forde-Thomas JE, Wilson S, Wawrzyniak J, Tukahebwa EM, Hoffmann KF, Chalmers IW. Gasan TA, et al. Among authors: forde thomas je. PLoS Negl Trop Dis. 2021 Nov 18;15(11):e0009981. doi: 10.1371/journal.pntd.0009981. eCollection 2021 Nov. PLoS Negl Trop Dis. 2021. PMID: 34793443 Free PMC article.
17 results