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Klebsiella pneumoniae clinical isolates with features of both multidrug-resistance and hypervirulence have unexpectedly low virulence.
Kochan TJ, Nozick SH, Valdes A, Mitra SD, Cheung BH, Lebrun-Corbin M, Medernach RL, Vessely MB, Mills JO, Axline CMR, Nelson JA, VanGosen EM, Ward TJ, Ozer EA, van Duin D, Chen L, Kreiswirth BN, Long SW, Musser JM, Bulman ZP, Wunderink RG, Hauser AR. Kochan TJ, et al. Among authors: chen l. Nat Commun. 2023 Dec 2;14(1):7962. doi: 10.1038/s41467-023-43802-1. Nat Commun. 2023. PMID: 38042959 Free PMC article.
Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae.
Deleo FR, Chen L, Porcella SF, Martens CA, Kobayashi SD, Porter AR, Chavda KD, Jacobs MR, Mathema B, Olsen RJ, Bonomo RA, Musser JM, Kreiswirth BN. Deleo FR, et al. Among authors: chen l. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4988-93. doi: 10.1073/pnas.1321364111. Epub 2014 Mar 17. Proc Natl Acad Sci U S A. 2014. PMID: 24639510 Free PMC article.
Carbapenem-resistant Klebsiella pneumoniae strains exhibit diversity in aminoglycoside-modifying enzymes, which exert differing effects on plazomicin and other agents.
Almaghrabi R, Clancy CJ, Doi Y, Hao B, Chen L, Shields RK, Press EG, Iovine NM, Townsend BM, Wagener MM, Kreiswirth B, Nguyen MH. Almaghrabi R, et al. Among authors: chen l. Antimicrob Agents Chemother. 2014 Aug;58(8):4443-51. doi: 10.1128/AAC.00099-14. Epub 2014 May 27. Antimicrob Agents Chemother. 2014. PMID: 24867988 Free PMC article.
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