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A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers.
Wranik M, Kepa MW, Beale EV, James D, Bertrand Q, Weinert T, Furrer A, Glover H, Gashi D, Carrillo M, Kondo Y, Stipp RT, Khusainov G, Nass K, Ozerov D, Cirelli C, Johnson PJM, Dworkowski F, Beale JH, Stubbs S, Zamofing T, Schneider M, Krauskopf K, Gao L, Thorn-Seshold O, Bostedt C, Bacellar C, Steinmetz MO, Milne C, Standfuss J. Wranik M, et al. Among authors: steinmetz mo. Nat Commun. 2023 Dec 2;14(1):7956. doi: 10.1038/s41467-023-43523-5. Nat Commun. 2023. PMID: 38042952 Free PMC article.
Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A.
Benoit RM, Frey D, Hilbert M, Kevenaar JT, Wieser MM, Stirnimann CU, McMillan D, Ceska T, Lebon F, Jaussi R, Steinmetz MO, Schertler GF, Hoogenraad CC, Capitani G, Kammerer RA. Benoit RM, et al. Among authors: steinmetz mo. Nature. 2014 Jan 2;505(7481):108-11. doi: 10.1038/nature12732. Epub 2013 Nov 17. Nature. 2014. PMID: 24240280
Fast native-SAD phasing for routine macromolecular structure determination.
Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, Zhou D, Rose J, Ebihara A, Kuramitsu S, Li D, Howe N, Schnapp G, Pautsch A, Bargsten K, Prota AE, Surana P, Kottur J, Nair DT, Basilico F, Cecatiello V, Pasqualato S, Boland A, Weichenrieder O, Wang BC, Steinmetz MO, Caffrey M, Wang M. Weinert T, et al. Among authors: steinmetz mo. Nat Methods. 2015 Feb;12(2):131-3. doi: 10.1038/nmeth.3211. Epub 2014 Dec 15. Nat Methods. 2015. PMID: 25506719
Data-collection strategy for challenging native SAD phasing.
Olieric V, Weinert T, Finke AD, Anders C, Li D, Olieric N, Borca CN, Steinmetz MO, Caffrey M, Jinek M, Wang M. Olieric V, et al. Among authors: steinmetz mo. Acta Crystallogr D Struct Biol. 2016 Mar;72(Pt 3):421-9. doi: 10.1107/S2059798315024110. Epub 2016 Mar 1. Acta Crystallogr D Struct Biol. 2016. PMID: 26960129 Free PMC article.
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Bohnacker T, Prota AE, Beaufils F, Burke JE, Melone A, Inglis AJ, Rageot D, Sele AM, Cmiljanovic V, Cmiljanovic N, Bargsten K, Aher A, Akhmanova A, Díaz JF, Fabbro D, Zvelebil M, Williams RL, Steinmetz MO, Wymann MP. Bohnacker T, et al. Among authors: steinmetz mo. Nat Commun. 2017 Mar 9;8:14683. doi: 10.1038/ncomms14683. Nat Commun. 2017. PMID: 28276440 Free PMC article.
Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.
Weinert T, Olieric N, Cheng R, Brünle S, James D, Ozerov D, Gashi D, Vera L, Marsh M, Jaeger K, Dworkowski F, Panepucci E, Basu S, Skopintsev P, Doré AS, Geng T, Cooke RM, Liang M, Prota AE, Panneels V, Nogly P, Ermler U, Schertler G, Hennig M, Steinmetz MO, Wang M, Standfuss J. Weinert T, et al. Among authors: steinmetz mo. Nat Commun. 2017 Sep 14;8(1):542. doi: 10.1038/s41467-017-00630-4. Nat Commun. 2017. PMID: 28912485 Free PMC article.
Advances in long-wavelength native phasing at X-ray free-electron lasers.
Nass K, Cheng R, Vera L, Mozzanica A, Redford S, Ozerov D, Basu S, James D, Knopp G, Cirelli C, Martiel I, Casadei C, Weinert T, Nogly P, Skopintsev P, Usov I, Leonarski F, Geng T, Rappas M, Doré AS, Cooke R, Nasrollahi Shirazi S, Dworkowski F, Sharpe M, Olieric N, Bacellar C, Bohinc R, Steinmetz MO, Schertler G, Abela R, Patthey L, Schmitt B, Hennig M, Standfuss J, Wang M, Milne CJ. Nass K, et al. Among authors: steinmetz mo. IUCrJ. 2020 Sep 9;7(Pt 6):965-975. doi: 10.1107/S2052252520011379. eCollection 2020 Nov 1. IUCrJ. 2020. PMID: 33209311 Free PMC article.
A Robust, GFP-Orthogonal Photoswitchable Inhibitor Scaffold Extends Optical Control over the Microtubule Cytoskeleton.
Gao L, Meiring JCM, Kraus Y, Wranik M, Weinert T, Pritzl SD, Bingham R, Ntouliou E, Jansen KI, Olieric N, Standfuss J, Kapitein LC, Lohmüller T, Ahlfeld J, Akhmanova A, Steinmetz MO, Thorn-Seshold O. Gao L, et al. Among authors: steinmetz mo. Cell Chem Biol. 2021 Feb 18;28(2):228-241.e6. doi: 10.1016/j.chembiol.2020.11.007. Epub 2020 Dec 3. Cell Chem Biol. 2021. PMID: 33275880 Free article.
In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M.
Gao L, Meiring JCM, Varady A, Ruider IE, Heise C, Wranik M, Velasco CD, Taylor JA, Terni B, Weinert T, Standfuss J, Cabernard CC, Llobet A, Steinmetz MO, Bausch AR, Distel M, Thorn-Seshold J, Akhmanova A, Thorn-Seshold O. Gao L, et al. Among authors: steinmetz mo. J Am Chem Soc. 2022 Mar 30;144(12):5614-5628. doi: 10.1021/jacs.2c01020. Epub 2022 Mar 15. J Am Chem Soc. 2022. PMID: 35290733 Free PMC article.
193 results